Document Detail

Retrospective cohort study of a new infant formula during the first 6 months of life: reflections on growth curves, human milk and formula feeding.
MedLine Citation:
PMID:  21243867     Owner:  NLM     Status:  In-Process    
BACKGROUND: Optimil is an infant formula, manufactured in Israel and introduced to the market in May 2008.
OBJECTIVES: To assess the effect of this formula on infant growth.
METHOD: The study group comprised 52 infants who for the first 6 months of life consumed Optimil, which constituted at least 25% of their total daily intake. Anthropometric data were collected from the records of the well-baby clinics. Weight, length and head circumference at baseline and 3 months thereafter were converted to gender and age-matched standard deviation Z-scores. As an exploratory uncontrolled analysis, questionnaires were sent to the caregivers to assess satisfaction with the formula and to note the rate of constipation, irritability and vomiting as well as apparent palatability.
RESULTS: The baseline Z-scores of all three parameters were below zero but increased significantly after 3 months (-0.2 +/- 0.88 to 0.12 +/- 0.88, P= 0.013 for weight; -0.44 +/- 0.87 to 0.10 +/- 0.72, P< 0.001 for length; and -0.58 +/- 0.78 to -0.1 +/- 0.76, P< 0.001 for head circumference). There was a significant dose-response effect of the formula with weight gain. The formula was generally well accepted, with 8% constipation, 8% vomiting and 6% significant irritability.
CONCLUSIONS: This study provides the first evidence that infants consuming Optimil under age 6 months have adequate growth. Nonetheless, breastfeeding during this period should be preferred in almost all cases.
Shmuel Hudara; Francis Mimouni; Yelena Rachman; Bosmat Dayan; Ari Silbermintz; Dan Turner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Israel Medical Association journal : IMAJ     Volume:  12     ISSN:  1565-1088     ISO Abbreviation:  Isr. Med. Assoc. J.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2011-01-19     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100930740     Medline TA:  Isr Med Assoc J     Country:  Israel    
Other Details:
Languages:  eng     Pagination:  676-80     Citation Subset:  IM    
Pediatric Gastroenterology and Nutrition Unit, Shaare Zedek Medical Center, Jerusalem, Israel.
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