Document Detail


Retrospective assessment of subacute or chronic osteomyelitis in children and young adults.
MedLine Citation:
PMID:  15248008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To identify factors associated with and to describe treatment outcomes of pediatric subacute or chronic osteomyelitis (S/CO), we retrospectively identified 52 patients with S/CO from January 1994 to November 1999 seen at a large pediatric hospital infectious disease clinic. S/CO was defined by the following: >10 days of clinical symptoms; radiographic, surgical, or pathologic changes consistent with S/CO; or relapse of prior osteomyelitis. Of these patients 63% were male, median age 9 years. Bones involved included vertebra (19% of subjects), femur (17%), finger (12%), humerus (10%), and tibia (8%). Sixty-five percent had at least 1 risk factor (most commonly hardware, neurologic disease or preceding trauma, sepsis, or surgery). Blood, bone, or wound aspirate cultures were positive in 67%, most commonly for Staphylococcus aureus. Erythrocyte sedimentation rate (ESR) was elevated in 88% of 41 patients at the time of diagnosis. Intravenous antibiotics were given for a median of 6 weeks and oral antibiotics for a median of 4.5 months. One child had a complication. In conclusion, consideration of S/CO should be high when predisposing factors are present. ESR may be useful for determining effectiveness and duration of therapy. With prolonged antibiotic therapy nearly all patients demonstrated resolution of disease.
Authors:
Jane S Auh; Helen J Binns; Ben Z Katz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical pediatrics     Volume:  43     ISSN:  0009-9228     ISO Abbreviation:  Clin Pediatr (Phila)     Publication Date:    2004 Jul-Aug
Date Detail:
Created Date:  2004-07-12     Completed Date:  2005-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372606     Medline TA:  Clin Pediatr (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  549-55     Citation Subset:  AIM; IM    
Affiliation:
Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Anti-Bacterial Agents / therapeutic use*
Cephalosporins / therapeutic use
Child
Child, Preschool
Chronic Disease
Clindamycin / therapeutic use
Female
Femur / pathology,  radiography
Fingers / pathology,  radiography
Humans
Humerus / pathology,  radiography
Infant
Male
Osteomyelitis / drug therapy*,  microbiology,  pathology
Oxacillin / therapeutic use
Retrospective Studies
Spine / pathology,  radiography
Staphylococcus aureus / drug effects
Streptococcus pneumoniae / drug effects
Streptococcus pyogenes / drug effects
Treatment Outcome
Vancomycin / therapeutic use
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Cephalosporins; 1404-90-6/Vancomycin; 18323-44-9/Clindamycin; 66-79-5/Oxacillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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