Document Detail

Retrospective analysis of treatment outcome of pediatric ependymomas in Korea: analysis of Korean multi-institutional data.
MedLine Citation:
PMID:  23462854     Owner:  NLM     Status:  MEDLINE    
We analyzed the treatment outcomes of intracranial ependymomas in Korean children aged <18 years. Data for 96 patients were collected from five hospitals. Survival rates were calculated using the Kaplan-Meier method. Log-rank tests for univariate analyses and Cox regression model for multivariate analysis were conducted to identify prognostic factors for survival. The median age of the patients was 4 years (range, 0.3-17.9 years). The median follow-up was 55 months (range, 2-343 months). Age <3 years was an important factor for selecting adjuvant therapy after surgery. Among children aged <3 and ≥ 3 years, adjuvant radiotherapy (RT) was applied to 55 and 84 %, respectively, and adjuvant chemotherapy to 52 and 10 %, respectively. The 5 year local progression-free survival (LPFS), disease-free survival (DFS), and overall survival (OS) rates were 54, 52, and 79 %, respectively. Gross total resection was the most significant prognostic factor for all survival endpoints. Age ≥ 3 years and RT were significant prognostic factors for superior LPFS and DFS. However, the significance of age was lost in multivariate analysis for DFS. LPFS, DFS, and OS were superior in patients who started RT within 44 days after surgery (the median time) than in patients who started RT later in the patients aged ≥ 3 years. Postoperative RT was a strong prognostic factor for intracranial ependymomas. Our results suggest that early use of RT is an essential component of treatment, and should be considered in young children.
Yeon-Joo Kim; Joo-Young Kim; Do Hoon Lim; Hyeon Jin Park; Jungnam Joo; Ki Woong Sung; Hyung Jin Shin; Seung-Ki Kim; Ji Hoon Phi; Il Han Kim; Kyung Duk Park; Seung-do Ahn; Jinhong Jung; Young-Shin Ra; Young Sin Rha; Dong-Seok Kim; Chang-Ok Suh
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Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2013-03-06
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  113     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-10-30     Revised Date:  2013-12-23    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-48     Citation Subset:  IM    
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MeSH Terms
Brain Neoplasms / mortality*,  therapy*
Chemotherapy, Adjuvant
Child, Preschool
Combined Modality Therapy
Disease-Free Survival
Ependymoma / mortality*,  therapy*
Kaplan-Meier Estimate
Korea / epidemiology
Neurosurgical Procedures
Proportional Hazards Models
Radiotherapy, Adjuvant
Retrospective Studies
Treatment Outcome
Erratum In:
J Neurooncol. 2013 Dec;115(3):523
Note: Rha, Young Sin [corrected to Ra, Young-Shin]

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