Document Detail


Retrospective analysis of treatment outcome of pediatric ependymomas in Korea: analysis of Korean multi-institutional data.
MedLine Citation:
PMID:  23462854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We analyzed the treatment outcomes of intracranial ependymomas in Korean children aged <18 years. Data for 96 patients were collected from five hospitals. Survival rates were calculated using the Kaplan-Meier method. Log-rank tests for univariate analyses and Cox regression model for multivariate analysis were conducted to identify prognostic factors for survival. The median age of the patients was 4 years (range, 0.3-17.9 years). The median follow-up was 55 months (range, 2-343 months). Age <3 years was an important factor for selecting adjuvant therapy after surgery. Among children aged <3 and ≥ 3 years, adjuvant radiotherapy (RT) was applied to 55 and 84 %, respectively, and adjuvant chemotherapy to 52 and 10 %, respectively. The 5 year local progression-free survival (LPFS), disease-free survival (DFS), and overall survival (OS) rates were 54, 52, and 79 %, respectively. Gross total resection was the most significant prognostic factor for all survival endpoints. Age ≥ 3 years and RT were significant prognostic factors for superior LPFS and DFS. However, the significance of age was lost in multivariate analysis for DFS. LPFS, DFS, and OS were superior in patients who started RT within 44 days after surgery (the median time) than in patients who started RT later in the patients aged ≥ 3 years. Postoperative RT was a strong prognostic factor for intracranial ependymomas. Our results suggest that early use of RT is an essential component of treatment, and should be considered in young children.
Authors:
Yeon-Joo Kim; Joo-Young Kim; Do Hoon Lim; Hyeon Jin Park; Jungnam Joo; Ki Woong Sung; Hyung Jin Shin; Seung-Ki Kim; Ji Hoon Phi; Il Han Kim; Kyung Duk Park; Seung-do Ahn; Jinhong Jung; Young-Shin Ra; Young Sin Rha; Dong-Seok Kim; Chang-Ok Suh
Related Documents :
16904984 - Profound hypothermia is superior to ultraprofound hypothermia in improving survival in ...
8479194 - The influence of surgical margins on advanced cancer treated with intraoperative radiat...
1715374 - Combined effects of hepatic arterial embolization using degradable starch microspheres ...
8312584 - 'patchwork' fields in thermoradiotherapy for extensive chest wall recurrences of breast...
8751224 - Extensive lymph node clearance for cancer of the esophagus or cardia: merits and limits...
3967084 - Multiple myeloma: significance of plasmablastic subtype in morphological classification.
Publication Detail:
Type:  Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't     Date:  2013-03-06
Journal Detail:
Title:  Journal of neuro-oncology     Volume:  113     ISSN:  1573-7373     ISO Abbreviation:  J. Neurooncol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-29     Completed Date:  2013-10-30     Revised Date:  2013-12-23    
Medline Journal Info:
Nlm Unique ID:  8309335     Medline TA:  J Neurooncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  39-48     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Brain Neoplasms / mortality*,  therapy*
Chemotherapy, Adjuvant
Child
Child, Preschool
Combined Modality Therapy
Disease-Free Survival
Ependymoma / mortality*,  therapy*
Female
Humans
Infant
Kaplan-Meier Estimate
Korea / epidemiology
Male
Neurosurgical Procedures
Proportional Hazards Models
Radiotherapy, Adjuvant
Retrospective Studies
Treatment Outcome
Comments/Corrections
Erratum In:
J Neurooncol. 2013 Dec;115(3):523
Note: Rha, Young Sin [corrected to Ra, Young-Shin]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The effect of tumor subtype on the time from primary diagnosis to development of brain metastases an...
Next Document:  Steroid management in newly diagnosed glioblastoma.