Document Detail

Retrospective analysis of the efficacy of cefotaxime sodium dosed twice daily. The Swedish experience.
MedLine Citation:
PMID:  7587033     Owner:  NLM     Status:  MEDLINE    
In a Swedish multicenter, comparative, retrospective study, patients with different types of infections--bacteremia-septicemia, genitourinary, intra-abdominal, central nervous system, and lower respiratory tract infections--were randomly selected from the hospital records. Patients treated with cefotaxime twice or three times a day as monotherapy (excluding metronidazole) for at least 1 day (240 cases) were analyzed in terms of clinical and bacteriologic outcome, these results were correlated with the dosing regimen. Similarly high success rates (cure and improvement) at hospital discharge were observed in both group initially treated with cefotaxime 1 g twice daily and 2 g twice daily (97 and 96%, respectively). A total of 73% of patients were initially treated with cefotaxime for only 3 days at most before changing to a lower dose regimen, an alternate intravenous treatment, or oral drug follow-up. Clinical evaluation at hospital discharge revealed a clinical success rate between 87 and 100%, depending on the type of infection.
S O Bergquist; I Eriksson; S Eriksson; N Lönnbro; A Runehagen; J Styrud; G Ahlquist
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  Diagnostic microbiology and infectious disease     Volume:  22     ISSN:  0732-8893     ISO Abbreviation:  Diagn. Microbiol. Infect. Dis.     Publication Date:    1995 May-Jun
Date Detail:
Created Date:  1995-12-05     Completed Date:  1995-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8305899     Medline TA:  Diagn Microbiol Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  163-6     Citation Subset:  IM    
Department of Infectious Diseases, Kalmar County Hospital, Sweden.
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MeSH Terms
Aged, 80 and over
Bacterial Infections / drug therapy*,  microbiology,  physiopathology
Cefotaxime / administration & dosage,  therapeutic use*
Cephalosporins / administration & dosage,  therapeutic use*
Child, Preschool
Dose-Response Relationship, Drug
Drug Administration Schedule
Middle Aged
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Cephalosporins; 63527-52-6/Cefotaxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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