| Retrospective analysis of clinical and microbiological aspects of Klebsiella oxytoca bacteremia over a 10-year period. | |
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MedLine Citation:
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PMID: 12111596 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From 1991 to 2000, 125 sporadic cases of Klebsiella oxytoca bacteremia were analyzed retrospectively to review clinical features and to identify the risk factors associated with resistance to extended-spectrum cephalosporins and fatal outcome. Bacteremia was acquired nosocomially in 52% of the patients. Almost all patients (97%) had an underlying disease, with biliary and pancreatic disease occurring most frequently (55%). The biliary tract was the most common site of infection (44%). Resistance to extended-spectrum cephalosporins was identified in 22 of the 125 (18%) Klebsiella oxytoca blood isolates and resistance to ciprofloxacin in 9 (7%). Only previous antibiotic therapy was strongly associated with resistance to extended-spectrum cephalosporins in patients with Klebsiella oxytoca bacteremia ( P=0.009). The mortality rate was 24% and was higher in patients infected with isolates resistant to extended-spectrum cephalosporins (41% vs. 20%; P=0.04). In multivariate analysis, fatal outcome was independently associated with septic shock, deteriorated mental status, polymicrobial bacteremia, and solid tumor. Surgical therapy had a protective effect (OR, 0.06; 95% CI, 0.005-0.7; P=0.03). In conclusion, Klebsiella oxytoca bacteremia was most commonly associated with biliary tract infection. Previous antibiotic therapy was strongly associated with resistance to extended-spectrum cephalosporins in patients with Klebsiella oxytoca bacteremia. |
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Authors:
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B N Kim; J Ryu; Y S Kim; J H Woo |
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Publication Detail:
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Type: Journal Article Date: 2002-06-12 |
Journal Detail:
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Title: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology Volume: 21 ISSN: 0934-9723 ISO Abbreviation: Eur. J. Clin. Microbiol. Infect. Dis. Publication Date: 2002 Jun |
Date Detail:
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Created Date: 2002-07-11 Completed Date: 2002-09-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8804297 Medline TA: Eur J Clin Microbiol Infect Dis Country: Germany |
Other Details:
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Languages: eng Pagination: 419-26 Citation Subset: IM |
Affiliation:
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Division of Infectious Diseases, Asan Medical Center, and Center for Antimicrobial Resistance and Microbial Genetics, University of Ulsan College of Medicine, Seoul, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Anti-Bacterial Agents / pharmacology*, therapeutic use Bacteremia* / drug therapy, microbiology, mortality, physiopathology Cephalosporins / pharmacology*, therapeutic use Child Child, Preschool Drug Resistance, Bacterial Female Humans Infant Infant, Newborn Klebsiella* / drug effects, pathogenicity Klebsiella Infections* / drug therapy, microbiology, mortality, physiopathology Male Microbial Sensitivity Tests Middle Aged Retrospective Studies Risk Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Cephalosporins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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