Document Detail

A Retrospective Study of Amitriptyline in Youth with Autism Spectrum Disorders.
MedLine Citation:
PMID:  23135317     Owner:  NLM     Status:  Publisher    
We performed a retrospective chart review of 50 youths with Autism Spectrum Disorder (ASD), prescribed amitriptyline (AMI) for hyperactivity and impulsivity. Data was systematically extracted from 50 outpatient clinic charts, including AMI treatment duration, dose, trough levels and adverse events. Mean age was 9.4 years (4.6-17.9); 40 were males and 10 females. 30 % had failed atomoxetine and 40 % had failed ≥3 ADHD medications. Mean dose was 1.3 ± 0.6 mg/kg/day, mean trough level 114.1 ± 50.5 ng/ml, mean duration 3.4 years. Clinical Global Impressions Scale-Improvement (CGI-I) was ≤2 in 60 % of patients at the final visit, and in 82 % of patients for at least 50 % of follow-ups. Cautious use of low dose AMI shows promise for treatment-resistant youth with ASD accompanied by hyperactivity, impulsivity, aggression and self injury.
Irfan Bhatti; Andrew Thome; Patricia Oxler Smith; Galen Cook-Wiens; Hung Wen Yeh; Gary R Gaffney; Jessica A Hellings
Related Documents :
8196507 - Inhibitory effects of antihypertensive drugs on mesangial cell proliferation after anti...
17854247 - Combination therapy of zonisamide and bupropion for weight reduction in obese women: a ...
9573077 - Validation of a volunteer model of cholera with frozen bacteria as the challenge.
9475257 - Celiprolol, a beta-adrenoceptor antagonist with vasodilator effect, improves hemodynami...
21172997 - Effect of defibrillation energy dose during in-hospital pediatric cardiac arrest.
9079787 - Neural mechanisms of tolerance to the effects of cocaine.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-8
Journal Detail:
Title:  Journal of autism and developmental disorders     Volume:  -     ISSN:  1573-3432     ISO Abbreviation:  J Autism Dev Disord     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7904301     Medline TA:  J Autism Dev Disord     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Division of Child and Adolescent Psychiatry, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hydration of arsenic oxyacid species.
Next Document:  Serum undercarboxylated osteocalcin level increases with 48 weeks of teriparatide treatment in pre-t...