Document Detail


Retrospective Analysis of Etomidate Versus Ketamine for First-pass Intubation Success in an Academic Emergency Department.
MedLine Citation:
PMID:  24552528     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVES: The objective of this study was to compare first-pass intubation success between patients who received etomidate versus ketamine for rapid sequence intubation (RSI) in the emergency department (ED).
METHODS: This was a retrospective analysis of prospectively collected data recorded in a quality improvement database between July 1, 2007, and December 31, 2012. The study was conducted in an academic ED in the United States. All patients who received etomidate or ketamine as part of RSI were included. The primary outcome measure was first-pass success. A multivariate analysis was conducted to determine if sedative type was associated with first-pass success, after adjusting for potential confounders and baseline differences.
RESULTS: The final cohort consisted of 2,098 RSI procedures using either etomidate (n = 1,983) or ketamine (n = 115). First-pass success occurred in 77.0% of patients in the etomidate group and 79.1% of patients in the ketamine group (difference = -2.1%; 95% CI = -5.5% to 9.8%). In the multivariate analysis, after adjusting for potential confounders, sedative type was not associated with first-pass success (odds ratio = 0.89; 95% CI = 0.5 to 1.5; p = 0.632).
CONCLUSIONS: Etomidate and ketamine are associated with equivalent first-pass success when used in RSI. Ketamine may be an appropriate alternative to etomidate for RSI in the ED.
Authors:
Asad E Patanwala; Courtney B McKinney; Brian L Erstad; John C Sakles
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Academic emergency medicine : official journal of the Society for Academic Emergency Medicine     Volume:  21     ISSN:  1553-2712     ISO Abbreviation:  Acad Emerg Med     Publication Date:  2014 Jan 
Date Detail:
Created Date:  2014-2-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9418450     Medline TA:  Acad Emerg Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  87-91     Citation Subset:  -    
Copyright Information:
© 2013 by the Society for Academic Emergency Medicine.
Vernacular Title:
Análisis Retrospectivo del Etomidato frente la Ketamina para la Intubación Exitosa en el Primer Intento en un Servicio de Urgencias Universitario.
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