Document Detail

Retroperitoneal fibrosis in two patients with Parkinson's disease treated with bromocriptine.
MedLine Citation:
PMID:  2177299     Owner:  NLM     Status:  MEDLINE    
Retroperitoneal fibrosis has been observed in two patients with Parkinson's disease treated with bromocriptine. The patients complained of abdominal or lower back pain and presented with various degrees of renal insufficiency, with anuria in one. Laboratory evaluation furthermore showed an increased sedimentation rate and inflammatory anemia. Computerized tomography disclosed marked retroperitoneal thickening, and biopsy was performed in one patient. The symptoms appeared eighteen months and five years after treatment was started, at doses of 20 and 22.5 mg of bromocriptine daily. The medication was discontinued in both patients and steroid therapy was initiated, with resolution of all clinical, biological and radiological evidence of disease. This potential but rare complication of a widely prescribed drug warrants monitoring of renal function and sedimentation rate in patients undergoing bromocriptine treatment.
J P Kains; J C Hardy; C Chevalier; A Collier
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Acta clinica Belgica     Volume:  45     ISSN:  1784-3286     ISO Abbreviation:  Acta Clin Belg     Publication Date:  1990  
Date Detail:
Created Date:  1991-02-28     Completed Date:  1991-02-28     Revised Date:  2014-03-18    
Medline Journal Info:
Nlm Unique ID:  0370306     Medline TA:  Acta Clin Belg     Country:  BELGIUM    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  IM    
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MeSH Terms
Bromocriptine / adverse effects*,  therapeutic use
Middle Aged
Parkinson Disease / drug therapy*
Retroperitoneal Fibrosis / chemically induced*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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