Document Detail

Retrograde modulation of presynaptic release probability through signaling mediated by PSD-95-neuroligin.
MedLine Citation:
PMID:  17237775     Owner:  NLM     Status:  MEDLINE    
The structure and function of presynaptic and postsynaptic components of the synapse are highly coordinated. How such coordination is achieved and the molecules involved in this process have not been clarified. Several lines of evidence suggest that presynaptic functionalities are regulated by retrograde mechanisms from the postsynaptic side. We therefore sought postsynaptic mechanisms responsible for trans-synaptic regulation of presynaptic function at excitatory synapses in rat hippocampal CA1 pyramidal neurons. We show here that the postsynaptic complex of scaffolding protein PSD-95 and neuroligin can modulate the release probability of transmitter vesicles at synapse in a retrograde way, resulting in altered presynaptic short-term plasticity. Presynaptic beta-neurexin serves as a likely presynaptic mediator of this effect. Our results indicate that trans-synaptic protein-protein interactions can link postsynaptic and presynaptic function.
Kensuke Futai; Myung Jong Kim; Tsutomu Hashikawa; Peter Scheiffele; Morgan Sheng; Yasunori Hayashi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-01-21
Journal Detail:
Title:  Nature neuroscience     Volume:  10     ISSN:  1097-6256     ISO Abbreviation:  Nat. Neurosci.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-29     Completed Date:  2007-04-03     Revised Date:  2008-03-27    
Medline Journal Info:
Nlm Unique ID:  9809671     Medline TA:  Nat Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-95     Citation Subset:  IM    
RIKEN-MIT Neuroscience Research Center, The Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
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MeSH Terms
Excitatory Postsynaptic Potentials / physiology
Hippocampus / cytology,  metabolism*
Intracellular Signaling Peptides and Proteins / metabolism*
Membrane Proteins / metabolism*
Nerve Tissue Proteins / metabolism*
Neuronal Plasticity / physiology
Neurotransmitter Agents / metabolism,  secretion
Organ Culture Techniques
Presynaptic Terminals / metabolism*,  ultrastructure
Protein Transport / physiology
Pyramidal Cells / metabolism,  secretion,  ultrastructure
Signal Transduction / physiology
Synaptic Membranes / metabolism*,  ultrastructure
Synaptic Transmission / physiology
Synaptic Vesicles / metabolism*,  secretion,  ultrastructure
Grant Support
Reg. No./Substance:
0/Dlgh4 protein, rat; 0/Intracellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Nerve Tissue Proteins; 0/Neurotransmitter Agents; 0/neuroligin 1; 156532-80-8/neurexin Ibeta
Erratum In:
Nat Neurosci. 2008 Feb;11(2):238

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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