Document Detail

Retinyl palmitate is a reproducible marker for chylomicron elimination from blood.
MedLine Citation:
PMID:  7709163     Owner:  NLM     Status:  MEDLINE    
To study the individual variation in chylomicron clearance rate, young healthy volunteers were given a p.o. dose of 50,000 IU retinyl palmitate in the morning to label their chylomicrons. Serial blood samples were then obtained in the time interval 4-8 h after retinyl palmitate intake, to closely monitor the clearance of retinyl ester from the blood. The procedure was repeated in an identical way two days later. The calculated individual halflives for retinyl palmitate clearance ranged from 1.54 to 9.90 h, i.e. a more than five-fold variation. The intraindividual variation was much less (relative SD 11%). Retinyl palmitate clearance (and probably chylomicron clearance) is, thus, relatively constant within the same individual on different occasions but varies considerably between individuals.
U Bitzén; M Winqvist; P Nilsson-Ehle; G Fex
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian journal of clinical and laboratory investigation     Volume:  54     ISSN:  0036-5513     ISO Abbreviation:  Scand. J. Clin. Lab. Invest.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-05-10     Completed Date:  1995-05-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404375     Medline TA:  Scand J Clin Lab Invest     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  611-3     Citation Subset:  IM    
Department of Clinical Chemistry, Lund University Hospital, Sweden.
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MeSH Terms
Biological Markers
Chylomicrons / blood*
Metabolic Clearance Rate
Vitamin A / analogs & derivatives*,  pharmacokinetics
Reg. No./Substance:
0/Biological Markers; 0/Chylomicrons; 11103-57-4/Vitamin A; 79-81-2/retinol palmitate

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