| Retinyl palmitate is a reproducible marker for chylomicron elimination from blood. | |
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MedLine Citation:
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PMID: 7709163 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To study the individual variation in chylomicron clearance rate, young healthy volunteers were given a p.o. dose of 50,000 IU retinyl palmitate in the morning to label their chylomicrons. Serial blood samples were then obtained in the time interval 4-8 h after retinyl palmitate intake, to closely monitor the clearance of retinyl ester from the blood. The procedure was repeated in an identical way two days later. The calculated individual halflives for retinyl palmitate clearance ranged from 1.54 to 9.90 h, i.e. a more than five-fold variation. The intraindividual variation was much less (relative SD 11%). Retinyl palmitate clearance (and probably chylomicron clearance) is, thus, relatively constant within the same individual on different occasions but varies considerably between individuals. |
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Authors:
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U Bitzén; M Winqvist; P Nilsson-Ehle; G Fex |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Scandinavian journal of clinical and laboratory investigation Volume: 54 ISSN: 0036-5513 ISO Abbreviation: Scand. J. Clin. Lab. Invest. Publication Date: 1994 Dec |
Date Detail:
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Created Date: 1995-05-10 Completed Date: 1995-05-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404375 Medline TA: Scand J Clin Lab Invest Country: NORWAY |
Other Details:
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Languages: eng Pagination: 611-3 Citation Subset: IM |
Affiliation:
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Department of Clinical Chemistry, Lund University Hospital, Sweden. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers Chylomicrons / blood* Female Half-Life Humans Male Metabolic Clearance Rate Vitamin A / analogs & derivatives*, pharmacokinetics |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Chylomicrons; 11103-57-4/Vitamin A; 79-81-2/retinol palmitate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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