| Retinyl esters in the vertebrate neuroretina. | |
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MedLine Citation:
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PMID: 2783537 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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High-performance liquid chromatography (HPLC) was employed to measure retinyl esters in the vertebrate retina. Both retina and retinal pigment epithelium (RPE) from frog, chicken, and bovine eyes were studied. In comparison to the RPE, the retina possessed a significant level of 11-cis and all trans retinyl palmitate. Using a sensitive radioassay, we also detected the presence of retinyl ester hydrolase (REH) activity in homogenates prepared from both retina and RPE. The rate of retinyl ester hydrolysis in these retinas was sufficiently high to supply retinal chromophores for the metabolic renewal and for the regeneration of visual pigments. In comparison to retinyl esters in the RPE, retinyl esters in the retina are located much closer to the sites of visual pigment synthesis and regeneration. Hence it is possible that these retinyl esters play a more important role in the visual cycle than those in the RPE. |
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Authors:
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K A Rodriguez; A T Tsin |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of physiology Volume: 256 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1989 Jan |
Date Detail:
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Created Date: 1989-02-23 Completed Date: 1989-02-23 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R255-8 Citation Subset: IM |
Affiliation:
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Division of Life Sciences, University of Texas, San Antonio 78285. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carboxylic Ester Hydrolases / metabolism Cattle Chickens Female Male Pigment Epithelium of Eye / metabolism Rana pipiens Vitamin A / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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EY-06438/EY/NEI NIH HHS; GM-07717/GM/NIGMS NIH HHS; RR-08194/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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11103-57-4/Vitamin A; EC 3.1.1.-/Carboxylic Ester Hydrolases; EC 3.1.1.-/retinyl esterase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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