Document Detail


Retinotopic organization in children measured with fMRI.
MedLine Citation:
PMID:  15330718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Many measures of visual function reach adult levels by about age 5, but some visual abilities continue to develop throughout adolescence. Little is known about the underlying functional anatomy of visual cortex in human infants or children. We used fMRI to measure the retinotopic organization of visual cortex in 15 children aged 7-12 years. Overall, we obtained adult-like patterns for most children tested. We found that significant head motion accounted for poor quality maps in a few tested children who were excluded from further analysis. When the maps from 10 children were compared with those obtained from 10 adults, the magnitude of retinotopic signals in visual areas V1, V2, V3, V3A, VP, and V4v was essentially the same between children and adults. Furthermore, one measure of intra-area organization, the cortical magnification function, did not significantly differ between adults and children for V1 or V2. However, quantitative analysis of visual area size revealed some significant differences beyond V1. Adults had larger extrastriate areas (V2, V3, VP, and V4v), when measured absolutely or as a proportion of the entire cortical sheet. We found that the extent and laterality of retinotopic signals beyond these classically defined areas, in parietal and lateral occipital cortex, showed some differences between adults and children. These data serve as a useful reference for studies of higher cognitive function in pediatric populations and for studies of children with vision disorders, such as amblyopia.
Authors:
Ian P Conner; Saloni Sharma; Susan K Lemieux; Janine D Mendola
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.     Date:  2004-06-18
Journal Detail:
Title:  Journal of vision     Volume:  4     ISSN:  1534-7362     ISO Abbreviation:  J Vis     Publication Date:  2004 Jun 
Date Detail:
Created Date:  2004-08-27     Completed Date:  2004-09-13     Revised Date:  2008-04-29    
Medline Journal Info:
Nlm Unique ID:  101147197     Medline TA:  J Vis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  509-23     Citation Subset:  IM    
Affiliation:
Department of Neurobiology & Anatomy, West Virginia University School of Medicine, Morgantown, WV, USA. iconner@wvu.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain Mapping
Child
Female
Humans
Magnetic Resonance Imaging
Male
Neurons / physiology
Retina / anatomy & histology*,  physiology
Visual Cortex / anatomy & histology*,  physiology
Visual Pathways / anatomy & histology*,  physiology
Grant Support
ID/Acronym/Agency:
P20 RR015574-010002/RR/NCRR NIH HHS; P20 RR015574-020002/RR/NCRR NIH HHS; P20 RR015574-030002/RR/NCRR NIH HHS; P20 RR015574-040002/RR/NCRR NIH HHS; P20RR15574/RR/NCRR NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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