| Retinopathy screening in patients with Type 1 diabetes diagnosed in young age using a Nonmydriatic Digital Stereoscopic Retinal Imaging. | |
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MedLine Citation:
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PMID: 21985859 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Background - Diabetic retinopathy seriously impairs patients' quality of life, since it represents the first cause of blindness in industrialized countries. Aim - To estimate prevalence of retinopathy in young type 1 diabetes patients using a Nonmydriatic Digital Stereoscopic Retinal Imaging (NMDSRI), and to evaluate the impact of socio-demographic, clinical and metabolic variables. Subjects and methods - In 247 young patients HbA1c, gender, age, pubertal stage, presence of diabetic ketoacidosis (DKA), HLA-DQ heterodimers of susceptibility for Type 1 diabetes and β-cell autoimmunity at clinical onset were considered. At retinopathy screening, we evaluated age, disease duration, pubertal stage, body mass index (BMI-SDS), insulin requirement, HbA1c levels, other autoimmune diseases, diabetes-related complications, serum concentrations of cholesterol and tryglicerides, systolic and diastolic blood pressure. Results - Retinopathy was found in 26/247patients: 25 showed background retinopathy, and 1 had a sight-threatening retinopathy. A significant relationship between retinopathy and female gender (p=0.01), duration of disease ≥15 years (p<0.0001), serum tryglicerides levels >65 mg/dL (p=0.012) and mean HbA1c ≥ 7.5% or >9% (p=0.0014) were found at the multivariate logistic analysis. Conclusions - Metabolic control is the most important modifiable factor and promotion of continuous educational process to reach a good metabolic control is a cornerstone to prevent microangiopathic complications. Symptoms appear when the complication is already established; a screening program with an early diagnosis is mandatory to prevent an irreversible damage. |
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Authors:
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N Minuto; V Emmanuele; M Vannati; C Russo; C Rebora; S Panarello; A Pistorio; R Lorini; G d'Annunzio |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-6 |
Journal Detail:
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Title: Journal of endocrinological investigation Volume: - ISSN: 1720-8386 ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7806594 Medline TA: J Endocrinol Invest Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Pediatric Clinic, University of Genoa, IRCCS G. Gaslini Institute, Genoa, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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