Retinopathy of prematurity outcome in infants with prethreshold retinopathy of prematurity and oxygen saturation >94% in room air: the high oxygen percentage in retinopathy of prematurity study.

Retinopathy of prematurity outcome in infants with prethreshold retinopathy of prematurity and oxygen saturation >94% in room air: the high oxygen percentage in retinopathy of prematurity study.

MedLine Citation:	PMID: 12205257 Owner: NLM Status: MEDLINE
Abstract/OtherAbstract:	OBJECTIVES: To determine the rate of progression from prethreshold to threshold retinopathy of prematurity (ROP) in infants excluded from Supplemental Therapeutic Oxygen for Prethreshold Retinopathy of Prematurity (STOP-ROP) because their median arterial oxygen saturation by pulse oximetry (SpO2) values were >94% in room air at the time of prethreshold diagnosis and to compare them with infants who were enrolled in STOP-ROP and had median SpO2 < or =94% in room air. METHODS: Fifteen of the 30 centers that participated in STOP-ROP elected to participate in the High Oxygen Percentage in Retinopathy of Prematurity study (HOPE-ROP) from January 1996 to March 1999. Infants were followed prospectively from the time prethreshold ROP was diagnosed until ROP either progressed to threshold in at least 1 study eye (adverse outcome) or resolved (favorable outcome). RESULTS: A total of 136 HOPE-ROP infants were compared with 229 STOP-ROP infants enrolled during the same time period from the same 15 hospitals. HOPE-ROP infants were of greater gestational age at birth (26.2 +/- 1.8 vs 25.2 +/- 1.4 weeks) and greater postmenstrual age at the time of prethreshold ROP diagnosis (36.7 +/- 2.5 vs 35.4 +/- 2.5 weeks). HOPE-ROP infants progressed to threshold ROP 25% of the time compared with 46% of STOP-ROP infants. After gestational age, race, postmenstrual age at prethreshold diagnosis, zone 1 disease, and plus disease at prethreshold diagnosis were controlled for, logistic regression analysis showed that HOPE-ROP infants progressed from prethreshold to threshold ROP less often than STOP-ROP infants (odds ratio: 0.607; 95% confidence interval: 0.359-1.026). CONCLUSIONS: The mechanisms that result in better ROP outcome for HOPE-ROP versus STOP-ROP are not fully understood. It seems that an infant's SpO2 value at the time of prethreshold diagnosis is a prognostic indicator for which infants may progress to severe ROP. When other known prognostic indicators are factored in, the SpO2 is of borderline significance.

Authors:	Mary Lou McGregor; Don L Bremer; Cynthia Cole; Richard E McClead; Dale L Phelps; Rae R Fellows; Neal Oden;
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Publication Detail:	Type: Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
Journal Detail:	Title: Pediatrics Volume: 110 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2002 Sep
Date Detail:	Created Date: 2002-09-02 Completed Date: 2002-10-09 Revised Date: 2007-11-14
Medline Journal Info:	Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States
Other Details:	Languages: eng Pagination: 540-4 Citation Subset: AIM; IM
Affiliation:	Department of Ophthalmology, The Ohio State University, Columbus, Ohio, USA. mcgregom@chi.osu.edu
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MeSH Terms
Descriptor/Qualifier:	Disease Progression Environment, Controlled Humans Infant, Newborn Infant, Premature Oximetry Oxygen Consumption* Oxygen Inhalation Therapy* Prognosis Prospective Studies Retinopathy of Prematurity / physiopathology, prevention & control
Grant Support
ID/Acronym/Agency:	HD-27-880/HD/NICHD NIH HHS; M01-RR00054/RR/NCRR NIH HHS; RR-00-070/RR/NCRR NIH HHS
Comments/Corrections
Comment In:	Pediatrics. 2002 Sep;110(3):615-6 [PMID: 12205267 ]

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