Document Detail

Retinopathy of prematurity and antenatal corticosteroids. The Italian ROP Study Group.
MedLine Citation:
PMID:  10021720     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: It is not known whether antenatal corticosteroids (ANS) can reduce the risk of retinopathy of prematurity (ROP). The aim of this study was to evaluate in a prospective cohort study the effect of ANS on ROP development and severity.
METHODS: All infants consecutively admitted to 14 centres from 1.1.1992 to 31.12.1993, with a gestational age < or = 30 weeks, no congenital anomalies, and who survived to 6 months, were enrolled (N = 380). Mean birth weight of the cohort was 1157 g; mean gestational age was 28.4 weeks. ROP stage 1-2 developed in 82 neonates; ROP stage 3-3+ in 57. Only 70 neonates (18.4%) received ANS prophylaxis.
RESULTS: ANS prophylaxis highly significantly reduced the risk of developing ROP [Odds ratio, (OR), 0.35; 95% confidence interval 0.17-0.71, logistic regression analysis], and that of severe (stage 3-3+) ROP (OR 0.07; 95% confidence interval: 0.02-0.34). Short gestation, low birth weight, bronchopulmonary dysplasia also were significantly associated with ROP development and severity; respiratory distress syndrome and not being treated with surfactant were significant risk factors for ROP severity.
CONCLUSIONS: ANS prophylaxis protected both against ROP development and against severe forms of ROP. Prematurity and respiratory morbidity still represent independent risk factors for ROP.
V Console; L Gagliardi; A De Giorgi; E De Ponti
Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Acta bio-medica de L'Ateneo parmense : organo della Società di medicina e scienze naturali di Parma     Volume:  68 Suppl 1     ISSN:  -     ISO Abbreviation:  Acta Biomed Ateneo Parmense     Publication Date:  1997  
Date Detail:
Created Date:  1999-03-03     Completed Date:  1999-03-03     Revised Date:  2013-06-24    
Medline Journal Info:
Nlm Unique ID:  8106323     Medline TA:  Acta Biomed Ateneo Parmense     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  75-9     Citation Subset:  IM    
Division of Neonatology and Neonatal Intensive Care Unit, Ospedale Niguarda, Milano.
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MeSH Terms
Adrenal Cortex Hormones / administration & dosage*
Cohort Studies
Confidence Intervals
Infant, Newborn
Infant, Premature
Italy / epidemiology
Logistic Models
Odds Ratio
Prenatal Care* / statistics & numerical data
Prospective Studies
Retinopathy of Prematurity / epidemiology,  prevention & control*
Risk Factors
Reg. No./Substance:
0/Adrenal Cortex Hormones

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