| Retinopathy of prematurity and antenatal corticosteroids. The Italian ROP Study Group. | |
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MedLine Citation:
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PMID: 10021720 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: It is not known whether antenatal corticosteroids (ANS) can reduce the risk of retinopathy of prematurity (ROP). The aim of this study was to evaluate in a prospective cohort study the effect of ANS on ROP development and severity. METHODS: All infants consecutively admitted to 14 centres from 1.1.1992 to 31.12.1993, with a gestational age < or = 30 weeks, no congenital anomalies, and who survived to 6 months, were enrolled (N = 380). Mean birth weight of the cohort was 1157 g; mean gestational age was 28.4 weeks. ROP stage 1-2 developed in 82 neonates; ROP stage 3-3+ in 57. Only 70 neonates (18.4%) received ANS prophylaxis. RESULTS: ANS prophylaxis highly significantly reduced the risk of developing ROP [Odds ratio, (OR), 0.35; 95% confidence interval 0.17-0.71, logistic regression analysis], and that of severe (stage 3-3+) ROP (OR 0.07; 95% confidence interval: 0.02-0.34). Short gestation, low birth weight, bronchopulmonary dysplasia also were significantly associated with ROP development and severity; respiratory distress syndrome and not being treated with surfactant were significant risk factors for ROP severity. CONCLUSIONS: ANS prophylaxis protected both against ROP development and against severe forms of ROP. Prematurity and respiratory morbidity still represent independent risk factors for ROP. |
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Authors:
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V Console; L Gagliardi; A De Giorgi; E De Ponti |
Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: Acta bio-medica de L'Ateneo parmense : organo della Società di medicina e scienze naturali di Parma Volume: 68 Suppl 1 ISSN: 0392-4203 ISO Abbreviation: Acta Biomed Ateneo Parmense Publication Date: 1997 |
Date Detail:
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Created Date: 1999-03-03 Completed Date: 1999-03-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8106323 Medline TA: Acta Biomed Ateneo Parmense Country: ITALY |
Other Details:
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Languages: eng Pagination: 75-9 Citation Subset: IM |
Affiliation:
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Division of Neonatology and Neonatal Intensive Care Unit, Ospedale Niguarda, Milano. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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administration & dosage* Cohort Studies Confidence Intervals Female Humans Infant, Newborn Infant, Premature Italy / epidemiology Logistic Models Odds Ratio Pregnancy Prenatal Care* / statistics & numerical data Prospective Studies Retinopathy of Prematurity / epidemiology, prevention & control* Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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