| Retinopathy signs in people without diabetes: the multi-ethnic study of atherosclerosis. | |
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MedLine Citation:
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PMID: 21055817 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To describe the prevalence of retinopathy and associations with cardiovascular risk factors in persons without diabetes in 4 racial/ethnic groups (white, black, Hispanic, and Chinese). DESIGN: Population-based, cross-sectional study. PARTICIPANTS: We included 6176 subjects aged 45-84 years without diabetes, selected from 6 United States communities. METHODS: Fundus images were taken using 45° digital camera through dark-adapted pupils and were graded for retinopathy as defined by the Early Treatment Diabetic Retinopathy Study severity scale: microaneurysms, hemorrhages, cotton wool spots, intraretinal microvascular abnormalities, hard exudates, venous beading, and new vessels. MAIN OUTCOME MEASURES: Retinopathy and the association with cardiovascular risk factors. RESULTS: Prevalence rates of retinopathy in persons without diabetes were 12.5% overall, varying from 11.9% (white), 13.9% (black), 12.6% (Hispanic), to 17.2% (Chinese). Hypertension was strongly associated with retinopathy (odds ratio [OR], 1.47; 95% confidence interval [CI], 1.23-1.75). After adjusting for age, gender, race, and other parameters, smoking (OR, 1.50; 95% CI, 1.09-2.06) and increased internal carotid intima media thickness (OR, 1.22; 95% CI, 1.05-1.41) were associated with retinopathy. A range of serum inflammatory factors were examined, but none were found to be significant. CONCLUSIONS: Retinopathy in persons without diabetes is common, varies with race/ethnicity, and associated with cardiovascular risk factors, including hypertension, smoking, and carotid artery intima media thickness. |
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Authors:
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Elvis Ojaimi; Thanh T Nguyen; Ronald Klein; F M Amirul Islam; Mary Frances Cotch; Barbara E K Klein; Jie-Jin Wang; Tien Yin Wong |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-11-04 |
Journal Detail:
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Title: Ophthalmology Volume: 118 ISSN: 1549-4713 ISO Abbreviation: Ophthalmology Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-04 Completed Date: 2011-06-06 Revised Date: 2012-04-04 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 656-62 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 American Academy of Ophthalmology. Published by Elsevier Inc. All rights reserved. |
Affiliation:
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Centre for Eye Research Australia, University of Melbourne, Australia. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Coronary Artery Disease / diagnosis*, ethnology Cross-Sectional Studies Diabetes Mellitus / diagnosis*, ethnology Diabetic Retinopathy / diagnosis*, ethnology Ethnic Groups / ethnology* Female Humans Male Middle Aged Prevalence Risk Factors Sex Distribution United States / epidemiology |
| Grant Support | |
ID/Acronym/Agency:
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HL69979-03/HL/NHLBI NIH HHS; N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95166/HC/NHLBI NIH HHS; N01-HC-95167/HC/NHLBI NIH HHS; N01-HC-95168/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; R01 HL069979-01/HL/NHLBI NIH HHS; Z01 EY000403-06/EY/NEI NIH HHS; Z01 EY000403-07/EY/NEI NIH HHS; Z99 EY999999/EY/NEI NIH HHS; ZIA EY000403-08/EY/NEI NIH HHS; ZIA EY000403-09/EY/NEI NIH HHS; ZIA EY000403-10/EY/NEI NIH HHS |
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