Document Detail

Retinol bound to physiological carrier molecules regulates growth and differentiation of myeloid leukemic cells.
MedLine Citation:
PMID:  3163997     Owner:  NLM     Status:  MEDLINE    
We have tested effects of retinol bound to its physiological carrier molecules, i.e. low density lipoprotein chylomicron remnants, and retinol binding protein (RBP) on differentiation and proliferation of myeloid leukemic cells in concentrations that can be obtained in vivo. Data presented in this study show that physiological concentrations of retinyl ester in chylomicron remnants induce differentiation and inhibit proliferation of the cell line HL-60 and promyelocytic leukemic cells in primary culture. Retinyl ester in low density lipoprotein showed no effect either on cell differentiation or proliferation of any of the myeloid cells tested. Retinol bound to RBP induced differentiation of HL-60 cells only in concentrations above those that can be found in vivo. However, cell proliferation was reduced both in HL-60 cells and in primary culture of leukemic cells using physiological concentrations of holo-RBP. These results suggest that retinyl ester in chylomicron remnants is the most effective vehicle for transport of retinol into leukemic cells in vivo.
K O Wathne; K R Norum; E Smeland; R Blomhoff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of biological chemistry     Volume:  263     ISSN:  0021-9258     ISO Abbreviation:  J. Biol. Chem.     Publication Date:  1988 Jun 
Date Detail:
Created Date:  1988-07-27     Completed Date:  1988-07-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2985121R     Medline TA:  J Biol Chem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  8691-5     Citation Subset:  IM    
Institute for Nutrition Research, School of Medicine, University of Oslo, Norway.
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MeSH Terms
Cell Differentiation*
Cell Division*
Cell Line
Leukemia, Myeloid, Acute
Lipoproteins / blood,  isolation & purification,  physiology*
Protein Binding
Retinol-Binding Proteins / isolation & purification,  physiology*
Vitamin A / blood*,  pharmacology
Reg. No./Substance:
0/Lipoproteins; 0/Retinol-Binding Proteins; 11103-57-4/Vitamin A

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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