Document Detail

Retinol binding protein 4 stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome proliferator-activated receptor-γ coactivator 1β-dependent pathway.
MedLine Citation:
PMID:  23300015     Owner:  NLM     Status:  MEDLINE    
CONCLUSION: These findings reveal a novel mechanism by which RBP4 achieves its effects on hepatic lipid metabolism.
Min Xia; Yan Liu; Honghui Guo; Duan Wang; Yun Wang; Wenhua Ling
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Publication Detail:
Type:  In Vitro; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-06-14
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  58     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-07-30     Completed Date:  2014-01-16     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  564-75     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Association for the Study of Liver Diseases.
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MeSH Terms
Cell Line, Tumor
Cyclic AMP Response Element-Binding Protein / metabolism
Hep G2 Cells / drug effects,  metabolism,  pathology
Lipogenesis / drug effects*
Liver / drug effects,  metabolism,  pathology
Mice, Inbred C57BL
Mice, Knockout
Models, Animal
Retinol-Binding Proteins, Plasma / pharmacology*
Signal Transduction / drug effects*
Sterol Regulatory Element Binding Protein 1 / metabolism*
Transcription Factors / deficiency,  genetics,  metabolism*
Up-Regulation / drug effects
Reg. No./Substance:
0/Creb1 protein, mouse; 0/Cyclic AMP Response Element-Binding Protein; 0/Ppargc1a protein, mouse; 0/Rbp4 protein, mouse; 0/Retinol-Binding Proteins, Plasma; 0/Srebf1 protein, mouse; 0/Sterol Regulatory Element Binding Protein 1; 0/Transcription Factors
Comment In:
Hepatology. 2014 Jun;59(6):2422   [PMID:  24115261 ]
Hepatology. 2013 Aug;58(2):477-9   [PMID:  23703940 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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