Document Detail

Retinol binding protein 4--a novel association with early-onset preeclampsia.
MedLine Citation:
PMID:  19708829     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Dysregulation of maternal circulating adipokines has been implicated in several "great obstetrical syndromes" including preeclampsia (PE), small-for-gestational age (SGA) neonate and fetal death (FD). It has been suggested that adipokines provide a molecular link between metabolic derangements and inflammatory response in complicated pregnancies. Retinol binding protein 4 (RBP4), a novel adipokine, plays a role in obesity-related disorders, as well as in the regulation of the immune response. The aim of this study was to determine whether there are changes in maternal plasma concentrations of RBP4 in patients with PE and in those with an SGA neonate or FD.
STUDY DESIGN: This cross-sectional study included patients in the following groups: 1) normal pregnancy (n=134); 2) PE (n=104); 3) SGA neonate (n=28); and 4) FD (n=37). Maternal plasma RBP4 concentrations were determined by ELISA. Non-parametric statistics were used for analysis.
RESULTS: 1) The median maternal plasma RBP4 concentration was higher among patients with PE than in those with a normal pregnancy (P=0.03); 2) The median maternal plasma RBP4 concentrations of patients with preterm PE (<37 weeks) was higher than that of those with term PE (P=0.017) and than that of those with a normal pregnancy (P=0.002); 3) The median maternal plasma RBP4 concentration did not differ significantly between patients with a normal pregnancy and those with an SGA neonate or with an FD; 4) Among normal pregnant women, the maternal plasma RBP4 concentrations did not correlate with pre-pregnancy body mass index, gestational age at blood sampling and neonatal birthweight.
CONCLUSIONS: 1) Preeclampsia, but not pregnancy with an SGA neonate or an FD, is associated with a higher median maternal plasma concentration of RBP4 than normal pregnancy; 2) Preterm PE, and specifically early-onset PE, is associated with higher median RBP4 concentrations in maternal plasma compared to term PE. These findings suggest a role for RBP4 in the pathogenesis of preterm PE, but not in SGA and FD.
Edi Vaisbuch; Roberto Romero; Shali Mazaki-Tovi; Offer Erez; Sun Kwon Kim; Tinnakorn Chaiworapongsa; Francesca Gotsch; Nandor Gabor Than; Zhong Dong; Percy Pacora; Ronald Lamont; Lami Yeo; Sonia S Hassan; Juan Pedro Kusanovic
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural    
Journal Detail:
Title:  Journal of perinatal medicine     Volume:  38     ISSN:  1619-3997     ISO Abbreviation:  J Perinat Med     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-04     Completed Date:  2010-06-03     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0361031     Medline TA:  J Perinat Med     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  129-39     Citation Subset:  IM    
Intramural Division, Perinatology Research Branch, NICHD/NIH/DHHS, Hutzel Women's Hospital, Bethesda, MD, USA.
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MeSH Terms
Cross-Sectional Studies
Fetal Death / blood*
Infant, Newborn
Infant, Small for Gestational Age / blood*
Pre-Eclampsia / blood*
Retinol-Binding Proteins, Plasma / metabolism*
Retrospective Studies
Statistics, Nonparametric
Young Adult
Grant Support
Reg. No./Substance:
0/RBP4 protein, human; 0/Retinol-Binding Proteins, Plasma

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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