| Retinoids in myelopoiesis. | |
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MedLine Citation:
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PMID: 12757021 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The vitamin A derivative retinoic acid plays a critical role during the differentiation of myeloid progenitors towards the neutrophil lineage. This role is primarily mediated by binding of retinoic acid to retinoic acid receptor alpha (RARalpha), a nuclear receptor that modulates the expression of multiple downstream targets via retinoic acid response elements. The importance of this signalling pathway in myelopoiesis is evidenced by the recurrent disruption of the RARalpha gene by chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). Biochemical evidence suggests RARalpha performs two opposing functions, one as a repressor of gene expression in the absence of ligand, the second as a transcriptional activator in the presence of ligand, each controlled by multimeric complexes of transcription corepressors and coactivators, respectively. Here the molecular mechanisms activated by retinoic acid during myelopoiesis in the context of neutrophil development will be reviewed, together with some of the more recently identified targets of the retinoic signalling pathway. |
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Authors:
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P Gaines; N Berliner |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of biological regulators and homeostatic agents Volume: 17 ISSN: 0393-974X ISO Abbreviation: J. Biol. Regul. Homeost. Agents Publication Date: 2003 Jan-Mar |
Date Detail:
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Created Date: 2003-05-21 Completed Date: 2003-08-05 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 8809253 Medline TA: J Biol Regul Homeost Agents Country: Italy |
Other Details:
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Languages: eng Pagination: 46-65 Citation Subset: IM |
Affiliation:
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Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA. peter.gaines@yale.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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ADP-ribosyl Cyclase
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metabolism Animals Antigens, CD / metabolism Antigens, CD38 Cell Differentiation Cyclin-Dependent Kinase Inhibitor p21 Cyclins / metabolism DNA-Binding Proteins / metabolism Gene Expression Regulation, Neoplastic Humans Kruppel-Like Transcription Factors Leukemia, Promyelocytic, Acute / metabolism, pathology Membrane Glycoproteins Myelopoiesis* Protein Kinases / metabolism Receptors, Retinoic Acid / genetics, metabolism* Retinoids / biosynthesis, metabolism* Signal Transduction Transcription Factors / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD; 0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Cyclins; 0/DNA-Binding Proteins; 0/Kruppel-Like Transcription Factors; 0/MZF1 protein, human; 0/Membrane Glycoproteins; 0/Receptors, Retinoic Acid; 0/Retinoids; 0/Transcription Factors; EC 2.7.-/Protein Kinases; EC 2.7.1.-/(CaM)-dependent protein kinase Ia kinase; EC 3.2.2.5/ADP-ribosyl Cyclase; EC 3.2.2.5/Antigens, CD38; EC 3.2.2.5/CD38 protein, human |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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