Document Detail

Retinoids in myelopoiesis.
MedLine Citation:
PMID:  12757021     Owner:  NLM     Status:  MEDLINE    
The vitamin A derivative retinoic acid plays a critical role during the differentiation of myeloid progenitors towards the neutrophil lineage. This role is primarily mediated by binding of retinoic acid to retinoic acid receptor alpha (RARalpha), a nuclear receptor that modulates the expression of multiple downstream targets via retinoic acid response elements. The importance of this signalling pathway in myelopoiesis is evidenced by the recurrent disruption of the RARalpha gene by chromosomal rearrangements in all cases of acute promyelocytic leukemia (APL). Biochemical evidence suggests RARalpha performs two opposing functions, one as a repressor of gene expression in the absence of ligand, the second as a transcriptional activator in the presence of ligand, each controlled by multimeric complexes of transcription corepressors and coactivators, respectively. Here the molecular mechanisms activated by retinoic acid during myelopoiesis in the context of neutrophil development will be reviewed, together with some of the more recently identified targets of the retinoic signalling pathway.
P Gaines; N Berliner
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of biological regulators and homeostatic agents     Volume:  17     ISSN:  0393-974X     ISO Abbreviation:  J. Biol. Regul. Homeost. Agents     Publication Date:    2003 Jan-Mar
Date Detail:
Created Date:  2003-05-21     Completed Date:  2003-08-05     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  8809253     Medline TA:  J Biol Regul Homeost Agents     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  46-65     Citation Subset:  IM    
Section of Hematology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
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MeSH Terms
ADP-ribosyl Cyclase / metabolism
Antigens, CD / metabolism
Antigens, CD38
Cell Differentiation
Cyclin-Dependent Kinase Inhibitor p21
Cyclins / metabolism
DNA-Binding Proteins / metabolism
Gene Expression Regulation, Neoplastic
Kruppel-Like Transcription Factors
Leukemia, Promyelocytic, Acute / metabolism,  pathology
Membrane Glycoproteins
Protein Kinases / metabolism
Receptors, Retinoic Acid / genetics,  metabolism*
Retinoids / biosynthesis,  metabolism*
Signal Transduction
Transcription Factors / metabolism
Reg. No./Substance:
0/Antigens, CD; 0/CDKN1A protein, human; 0/Cyclin-Dependent Kinase Inhibitor p21; 0/Cyclins; 0/DNA-Binding Proteins; 0/Kruppel-Like Transcription Factors; 0/MZF1 protein, human; 0/Membrane Glycoproteins; 0/Receptors, Retinoic Acid; 0/Retinoids; 0/Transcription Factors; EC 2.7.-/Protein Kinases; EC 2.7.1.-/(CaM)-dependent protein kinase Ia kinase; EC Cyclase; EC, CD38; EC protein, human

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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