Document Detail

Retinoids in cosmeceuticals.
MedLine Citation:
PMID:  17014484     Owner:  NLM     Status:  MEDLINE    
Retinoids are natural and synthetic vitamin A derivatives. They are lipophilic molecules and easily penetrate the epidermis. Their biologically active forms can modulate the expression of genes involved in cellular differentiation and proliferation. Retinoic acid (tretinoin), its 13-cis isomer isotretinoin, as well as various synthetic retinoids are used for therapeutic purposes, whereas retinaldehyde, retinol, and retinyl esters, because of their controlled conversion to retinoic acid or their direct receptor-independent biologic action, can be used as cosmeceuticals. These natural retinoic acid precursors are thus expected to be helpful in (i) renewing epidermal cells, (ii) acting as UV filters, (iii) preventing oxidative stress, (iv) controlling cutaneous bacterial flora, and (v) improving skin aging and photoaging. Retinol and retinyl esters are not irritant, whereas demonstrating only a modest clinical efficiency. On the other hand, retinaldehyde, which is fairly well tolerated, seems to be the most efficient cosmeceutical retinoid; it has significant efficiency toward oxidative stress, cutaneous bacterial flora, epidermis renewing, and photoaging.
Olivier Sorg; Christophe Antille; Gürkan Kaya; Jean-Hilaire Saurat
Related Documents :
11835684 - Retinoic acid exacerbates experimental radiation nephropathy.
4524614 - Mechanism of lysergic acid diethylamide interference with rabbit antibody biosynthesis.
16547054 - Genes and enzymes involved in caffeic acid biosynthesis in the actinomycete saccharothr...
11896294 - Prevention of vitamin a teratogenesis by phytol or phytanic acid results from reduced m...
1761514 - Composition of long chain bases in ceramide of the guinea pig harderian gland.
2315264 - Influence of paracetamol and acetylsalicylic acid on the toxicokinetics of toluene.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Dermatologic therapy     Volume:  19     ISSN:  1396-0296     ISO Abbreviation:  Dermatol Ther     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-10-03     Completed Date:  2007-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9700070     Medline TA:  Dermatol Ther     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  289-96     Citation Subset:  IM    
Clinique de Dermatologie, Geneva University Hospital, Geneva, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Administration, Topical
Cosmetics / administration & dosage*
Retinoids / administration & dosage*
Skin Aging / drug effects*
Reg. No./Substance:
0/Cosmetics; 0/Retinoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Retinoid therapy of pigmentary disorders.
Next Document:  The use of retinoids in the treatment of photoaging.