Document Detail


Retinoids in cosmeceuticals.
MedLine Citation:
PMID:  17014484     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinoids are natural and synthetic vitamin A derivatives. They are lipophilic molecules and easily penetrate the epidermis. Their biologically active forms can modulate the expression of genes involved in cellular differentiation and proliferation. Retinoic acid (tretinoin), its 13-cis isomer isotretinoin, as well as various synthetic retinoids are used for therapeutic purposes, whereas retinaldehyde, retinol, and retinyl esters, because of their controlled conversion to retinoic acid or their direct receptor-independent biologic action, can be used as cosmeceuticals. These natural retinoic acid precursors are thus expected to be helpful in (i) renewing epidermal cells, (ii) acting as UV filters, (iii) preventing oxidative stress, (iv) controlling cutaneous bacterial flora, and (v) improving skin aging and photoaging. Retinol and retinyl esters are not irritant, whereas demonstrating only a modest clinical efficiency. On the other hand, retinaldehyde, which is fairly well tolerated, seems to be the most efficient cosmeceutical retinoid; it has significant efficiency toward oxidative stress, cutaneous bacterial flora, epidermis renewing, and photoaging.
Authors:
Olivier Sorg; Christophe Antille; Gürkan Kaya; Jean-Hilaire Saurat
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Dermatologic therapy     Volume:  19     ISSN:  1396-0296     ISO Abbreviation:  Dermatol Ther     Publication Date:    2006 Sep-Oct
Date Detail:
Created Date:  2006-10-03     Completed Date:  2007-01-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9700070     Medline TA:  Dermatol Ther     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  289-96     Citation Subset:  IM    
Affiliation:
Clinique de Dermatologie, Geneva University Hospital, Geneva, Switzerland. olivier.sorg@hcuge.ch
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MeSH Terms
Descriptor/Qualifier:
Administration, Topical
Cosmetics / administration & dosage*
Humans
Retinoids / administration & dosage*
Skin Aging / drug effects*
Chemical
Reg. No./Substance:
0/Cosmetics; 0/Retinoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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