| Retinoids and epigenetic silencing in cancer. | |
MedLine Citation:
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PMID: 13677591 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An epigenetic event alters the activity of genes without changing their structure. Methylation reactions are important mediators of epigenetic events in cells. Two recent studies have established a mechanistic link between a vitamin A metabolite and epigenetic alterations of its target promoter that could provide insights about the role of vitamin A in cancer prevention. |
Authors:
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Gary L Johanning; Chandrika J Piyathilake |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Nutrition reviews Volume: 61 ISSN: 0029-6643 ISO Abbreviation: Nutr. Rev. Publication Date: 2003 Aug |
Date Detail:
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Created Date: 2003-09-17 Completed Date: 2003-10-20 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0376405 Medline TA: Nutr Rev Country: United States |
Other Details:
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Languages: eng Pagination: 284-9 Citation Subset: IM |
Affiliation:
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Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294-3360, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Transformation, Neoplastic
/
drug effects,
genetics DNA Methylation / drug effects DNA, Neoplasm / genetics* Gene Expression Regulation, Neoplastic / drug effects* Gene Silencing / drug effects* Humans Neoplasms / genetics, prevention & control* Retinoids / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/DNA, Neoplasm; 0/Retinoids |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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