Document Detail

Retinoids and epigenetic silencing in cancer.
MedLine Citation:
PMID:  13677591     Owner:  NLM     Status:  MEDLINE    
An epigenetic event alters the activity of genes without changing their structure. Methylation reactions are important mediators of epigenetic events in cells. Two recent studies have established a mechanistic link between a vitamin A metabolite and epigenetic alterations of its target promoter that could provide insights about the role of vitamin A in cancer prevention.
Gary L Johanning; Chandrika J Piyathilake
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Nutrition reviews     Volume:  61     ISSN:  0029-6643     ISO Abbreviation:  Nutr. Rev.     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-09-17     Completed Date:  2003-10-20     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0376405     Medline TA:  Nutr Rev     Country:  United States    
Other Details:
Languages:  eng     Pagination:  284-9     Citation Subset:  IM    
Department of Nutrition Sciences, The University of Alabama at Birmingham, Birmingham, AL 35294-3360, USA.
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MeSH Terms
Cell Transformation, Neoplastic / drug effects,  genetics
DNA Methylation / drug effects
DNA, Neoplasm / genetics*
Gene Expression Regulation, Neoplastic / drug effects*
Gene Silencing / drug effects*
Neoplasms / genetics,  prevention & control*
Retinoids / pharmacology*
Reg. No./Substance:
0/DNA, Neoplasm; 0/Retinoids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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