| Retinoid signaling and cardiac anteroposterior segmentation. | |
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MedLine Citation:
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PMID: 11747199 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Establishment of anterior-posterior polarity is one of the earliest decisions in cardiogenesis. Specification of anterior (outflow) and posterior (inflow) structures ensures proper connections between venous system and inflow tract and between arterial tree and outflow tract. The last few years have witnessed remarkable progress in our understanding of cardiac anteroposterior patterning. Molecular cloning and subsequent studies on RALDH2, the key embryonic retinaldehyde dehydrogenase in retinoic acid (RA) synthesis, provided the missing link between teratogenic studies on RA deficiency and excess and normal chamber morphogenesis. We discuss work establishing the foundations of our current understanding of the mechanisms of cardiac anteroposterior segmentation, the reasons why early evidence pointing to the role of RA in anteroposterior segmentation was overlooked, and the key experiments unraveling the role of RA in cardiac anteroposterior segmentation. We have also integrated recent experiments in a model of cardiac anteroposterior patterning in which RALDH2 expression determines anteroposterior boundaries in the heart field. |
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Authors:
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J Xavier-Neto; N Rosenthal; F A Silva; T G Matos; T Hochgreb; V L Linhares |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Genesis (New York, N.Y. : 2000) Volume: 31 ISSN: 1526-954X ISO Abbreviation: Genesis Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-12-17 Completed Date: 2002-03-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 100931242 Medline TA: Genesis Country: United States |
Other Details:
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Languages: eng Pagination: 97-104 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Wiley-Liss, Inc. |
Affiliation:
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Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicao da Faculdade de Medicine, Universidade de São Paulo 05403-000, São Paulo, Brazil. Xavier.Neto@incor.usp.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Gene Expression Regulation, Developmental / physiology Heart / embryology* Humans Mice Morphogenesis Signal Transduction / physiology* Transcription Factors / physiology Tretinoin / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Transcription Factors; 302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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