Document Detail

Retinoid signaling and cardiac anteroposterior segmentation.
MedLine Citation:
PMID:  11747199     Owner:  NLM     Status:  MEDLINE    
Establishment of anterior-posterior polarity is one of the earliest decisions in cardiogenesis. Specification of anterior (outflow) and posterior (inflow) structures ensures proper connections between venous system and inflow tract and between arterial tree and outflow tract. The last few years have witnessed remarkable progress in our understanding of cardiac anteroposterior patterning. Molecular cloning and subsequent studies on RALDH2, the key embryonic retinaldehyde dehydrogenase in retinoic acid (RA) synthesis, provided the missing link between teratogenic studies on RA deficiency and excess and normal chamber morphogenesis. We discuss work establishing the foundations of our current understanding of the mechanisms of cardiac anteroposterior segmentation, the reasons why early evidence pointing to the role of RA in anteroposterior segmentation was overlooked, and the key experiments unraveling the role of RA in cardiac anteroposterior segmentation. We have also integrated recent experiments in a model of cardiac anteroposterior patterning in which RALDH2 expression determines anteroposterior boundaries in the heart field.
J Xavier-Neto; N Rosenthal; F A Silva; T G Matos; T Hochgreb; V L Linhares
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Genesis (New York, N.Y. : 2000)     Volume:  31     ISSN:  1526-954X     ISO Abbreviation:  Genesis     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-03-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100931242     Medline TA:  Genesis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  97-104     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Wiley-Liss, Inc.
Laboratório de Genética e Cardiologia Molecular, Hospital das Clínicao da Faculdade de Medicine, Universidade de São Paulo 05403-000, São Paulo, Brazil.
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MeSH Terms
Gene Expression Regulation, Developmental / physiology
Heart / embryology*
Signal Transduction / physiology*
Transcription Factors / physiology
Tretinoin / physiology*
Reg. No./Substance:
0/Transcription Factors; 302-79-4/Tretinoin

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