Document Detail

Retinoid effects on photodamaged skin.
MedLine Citation:
PMID:  2087188     Owner:  NLM     Status:  MEDLINE    
The effects of retinoid treatment on wrinkling in the hairless mouse can be understood in the context of the repair of the dermal elastosis. The two isomers of retinoic acid do not differ qualitatively in their effects on the histological appearance of the tissue or on the wrinkling patterns produced. The all-trans isomer is slightly more potent in this system than the 13-cis isomer but substantially more irritating, which may limit the maximum degree of repair attainable. The "reconstructed" dermis is thickened, it contains new collagen as a result of the stimulation of gene expression, and the tangled, disorganized elastin is packed into a thin layer in the lower dermis. Thus, the framework within which a wrinkle had been established is eliminated, and the skin assumes a normal state, as observed. That the effacement is apparently permanent is additional evidence of the relationship between the integrity of the elastic fiber network and the surface appearance. The only difference in the repaired skin is the absence of filamentous surface features. The thickening effect of UVB and subsequent retinoid treatment on the epidermis does not contribute substantially to the overall thickness of the repaired skin. Nevertheless, despite having a minor role in the effacement of deep wrinkles, these epidermal changes evidently preclude the formation of fine surface features. The model is a valid one for the repair of photodamaged skin. From what is known about the role of elastin in maintaining skin integrity and from the association of wrinkling with excessive sun exposure, it is encouraging to observe the dual effect of retinoic acids.(ABSTRACT TRUNCATED AT 250 WORDS)
G F Bryce; S S Shapiro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Methods in enzymology     Volume:  190     ISSN:  0076-6879     ISO Abbreviation:  Meth. Enzymol.     Publication Date:  1990  
Date Detail:
Created Date:  1991-05-22     Completed Date:  1991-05-22     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0212271     Medline TA:  Methods Enzymol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  352-60     Citation Subset:  IM    
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MeSH Terms
Desmosine / analysis
Mice, Hairless
Reference Values
Skin / drug effects,  pathology,  radiation effects*
Skin Aging / drug effects*
Tretinoin / pharmacology*
Ultraviolet Rays*
Reg. No./Substance:
11003-57-9/Desmosine; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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