Document Detail

Retinoid concentrations in the mouse during postnatal development and after maternal vitamin A supplementation.
MedLine Citation:
PMID:  16113519     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitamin A (VA) and its derivates (retinoids) are important nutritional substances, which mediate their biological activity mainly via nuclear retinoid receptors. Maternal VA intake during lactation influences the VA content in milk and the VA status of the progeny. We investigated the effects of maternal supplementation during lactation and direct supplementation to the pups after weaning on the retinoid concentration in serum and liver of neonatal mice using high doses of VA. METHODS: Dams were fed a basal (4,500 retinol equivalents/kg diet) or a VA-supplemented (324,000 retinol equivalents/kg diet) diet during lactation. Pups kept receiving the same diet after weaning. Serum and liver samples of the pups were collected during lactation at days 1, 3, 5, 7, and 14 and post-weaning at days 21 and 65 after birth. Samples were analysed for retinoids by high-performance liquid chromatography. RESULTS: Maternal VA supplementation resulted in significantly higher concentrations of retinol, retinyl palmitate and retinyl stearate in serum of mice neonates at days 5, 7, 14, 21 and 65 after birth in comparison to the basal diet, whereas significantly higher concentrations were observed in liver at days 5, 14, 21 and 65 after birth. At day 7 after birth, a decrease in the liver retinoid concentrations occurred in the VA-supplemented diet. CONCLUSION: Our results show for the first time that supplementation with high doses of VA during the lactation period in mice can affect serum retinol concentrations in the neonates and report that day 7 after birth is a critical time in the tissue distribution of retinoids during postnatal development.
Ada L García; Ralph Ruhl; Florian J Schweigert
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-08-19
Journal Detail:
Title:  Annals of nutrition & metabolism     Volume:  49     ISSN:  0250-6807     ISO Abbreviation:  Ann. Nutr. Metab.     Publication Date:    2005 Sep-Oct
Date Detail:
Created Date:  2005-09-13     Completed Date:  2005-12-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8105511     Medline TA:  Ann Nutr Metab     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  333-41     Citation Subset:  IM    
Department of Nutritional Physiology and Pathophysiology, Institute of Nutritional Science, University of Potsdam, Potsdam-Rehbrücke, Germany.
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MeSH Terms
Animal Feed
Animals, Suckling / growth & development,  metabolism
Chromatography, High Pressure Liquid / methods
Dietary Supplements
Dose-Response Relationship, Drug
Lactation / metabolism*
Liver / metabolism*
Milk / chemistry*
Retinoids / blood,  metabolism*
Vitamin A / administration & dosage*,  pharmacokinetics
Vitamins / administration & dosage*,  pharmacokinetics
Reg. No./Substance:
0/Retinoids; 0/Vitamins; 11103-57-4/Vitamin A

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