| Retinoic acid (vitamin A acid) induced transcriptional control of interferon production. | |
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MedLine Citation:
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PMID: 271959 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The production of interferon was used to study the site and mechanism of action of retinoic acid (vitamin A). The data are consistent with a site of action at the gene level, because it appears that interferon production is blocked at the transcriptional step by a retinoic acid-induced protein. (i) The effect of retinoic acid is probably on an early cellular function associated with interferon production rather than an effect on the inducer [virus or poly(I).poly(C)]. (ii) The suppression of interferon production by retinoic acid is blocked by cycloheximide, indicating that a newly synthesized protein (repressor) mediates the suppression. (iii) When allowances are made for the time required for the synthesis of the retinoic acid-induced protein, the time course of retinoic acid suppression of interferon production is superimposable on the time course of actinomycin D suppression because the slopes are parallel. These data provide evidence for transcriptional control of a specific protein (interferon) by retinoic acid. Additionally, they support the existence of transcriptional control of interferon production after addition of inducer. |
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Authors:
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J E Blalock; G E Gifford |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 74 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1977 Dec |
Date Detail:
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Created Date: 1978-03-21 Completed Date: 1978-03-21 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 5382-6 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cycloheximide
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pharmacology Dactinomycin / pharmacology Interferon Inducers / pharmacology Interferons / biosynthesis*, genetics Kinetics L Cells (Cell Line) RNA, Messenger / biosynthesis Transcription, Genetic / drug effects* Tretinoin / pharmacology* Vitamin A / analogs & derivatives* |
| Chemical | |
Reg. No./Substance:
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0/Interferon Inducers; 0/RNA, Messenger; 11103-57-4/Vitamin A; 302-79-4/Tretinoin; 50-76-0/Dactinomycin; 66-81-9/Cycloheximide; 9008-11-1/Interferons |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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