Document Detail

Retinoic acid synthesis and signaling during early organogenesis.
MedLine Citation:
PMID:  18805086     Owner:  NLM     Status:  MEDLINE    
Retinoic acid, a derivative of vitamin A, is an essential component of cell-cell signaling during vertebrate organogenesis. In early development, retinoic acid organizes the trunk by providing an instructive signal for posterior neuroectoderm and foregut endoderm and a permissive signal for trunk mesoderm differentiation. At later stages, retinoic acid contributes to the development of the eye and other organs. Recent studies suggest that retinoic acid may act primarily in a paracrine manner and provide insight into the cell-cell signaling networks that control differentiation of pluripotent cells.
Gregg Duester
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell     Volume:  134     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-22     Completed Date:  2008-10-09     Revised Date:  2014-11-09    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  921-31     Citation Subset:  IM    
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MeSH Terms
Cell Differentiation
Signal Transduction*
Tretinoin / metabolism*
Grant Support
EY013969/EY/NEI NIH HHS; GM062848/GM/NIGMS NIH HHS; R01 EY013969/EY/NEI NIH HHS; R01 EY013969-06/EY/NEI NIH HHS; R01 GM062848/GM/NIGMS NIH HHS; R01 GM062848-06/GM/NIGMS NIH HHS
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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