Document Detail


Retinoic acid repression of bone morphogenetic protein 4 in inner ear development.
MedLine Citation:
PMID:  12640113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Bone morphogenetic protein 4 (BMP4) and retinoic acid are important for normal development of the inner ear, but whether they are linked mechanistically is not known. BMP4 antagonists disrupt semicircular canal formation, as does exposure to retinoic acid. We demonstrate that retinoic acid directly down-regulates BMP4 transcription in a mouse inner ear-derived cell line, and we identify a novel promoter in the second intron of the BMP4 gene that is a target of this regulation both in the cell line and in the mouse embryonic inner ear in vivo. The importance of this down-regulation is demonstrated in chicken embryos by showing that the retinoic acid effect on semicircular canal development can be overcome by exogenous BMP4.
Authors:
Deborah L Thompson; Lisa M Gerlach-Bank; Kate F Barald; Ronald J Koenig
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Molecular and cellular biology     Volume:  23     ISSN:  0270-7306     ISO Abbreviation:  Mol. Cell. Biol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-03-17     Completed Date:  2003-04-04     Revised Date:  2013-04-18    
Medline Journal Info:
Nlm Unique ID:  8109087     Medline TA:  Mol Cell Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2277-86     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Endocrinology Division, University of Michigan, Ann Arbor, Michigan 48109-0678, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Benzoates / pharmacology
Bone Morphogenetic Protein 4
Bone Morphogenetic Proteins / antagonists & inhibitors,  pharmacology,  physiology*
Cell Line
Chick Embryo
Ear, Inner / cytology,  drug effects,  embryology,  metabolism*
Gene Expression Regulation, Developmental / drug effects,  physiology
Introns
Mice
Promoter Regions, Genetic / physiology
RNA / metabolism
Receptors, Retinoic Acid / genetics,  metabolism
Retinoids / pharmacology
Transcription, Genetic / physiology
Tretinoin / pharmacology,  physiology*
Grant Support
ID/Acronym/Agency:
5 T32 DC00011/DC/NIDCD NIH HHS; GM07315/GM/NIGMS NIH HHS; P60 DK020574/DK/NIDDK NIH HHS; R01 DC04184/DC/NIDCD NIH HHS
Chemical
Reg. No./Substance:
0/Benzoates; 0/Bmp4 protein, mouse; 0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Proteins; 0/Receptors, Retinoic Acid; 0/Retinoids; 0/retinoic acid receptor alpha; 0/retinoic acid receptor beta; 302-79-4/Tretinoin; 63231-63-0/RNA; 71441-28-6/4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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