| Retinoic acid repression of bone morphogenetic protein 4 in inner ear development. | |
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MedLine Citation:
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PMID: 12640113 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Bone morphogenetic protein 4 (BMP4) and retinoic acid are important for normal development of the inner ear, but whether they are linked mechanistically is not known. BMP4 antagonists disrupt semicircular canal formation, as does exposure to retinoic acid. We demonstrate that retinoic acid directly down-regulates BMP4 transcription in a mouse inner ear-derived cell line, and we identify a novel promoter in the second intron of the BMP4 gene that is a target of this regulation both in the cell line and in the mouse embryonic inner ear in vivo. The importance of this down-regulation is demonstrated in chicken embryos by showing that the retinoic acid effect on semicircular canal development can be overcome by exogenous BMP4. |
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Authors:
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Deborah L Thompson; Lisa M Gerlach-Bank; Kate F Barald; Ronald J Koenig |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Molecular and cellular biology Volume: 23 ISSN: 0270-7306 ISO Abbreviation: Mol. Cell. Biol. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-17 Completed Date: 2003-04-04 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 8109087 Medline TA: Mol Cell Biol Country: United States |
Other Details:
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Languages: eng Pagination: 2277-86 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Endocrinology Division, University of Michigan, Ann Arbor, Michigan 48109-0678, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzoates / pharmacology Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins / antagonists & inhibitors, pharmacology, physiology* Cell Line Chick Embryo Ear, Inner / cytology, drug effects, embryology, metabolism* Gene Expression Regulation, Developmental / drug effects, physiology Introns Mice Promoter Regions, Genetic / physiology RNA / metabolism Receptors, Retinoic Acid / genetics, metabolism Retinoids / pharmacology Transcription, Genetic / physiology Tretinoin / pharmacology, physiology* |
| Grant Support | |
ID/Acronym/Agency:
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5 T32 DC00011/DC/NIDCD NIH HHS; GM07315/GM/NIGMS NIH HHS; P60 DK020574/DK/NIDDK NIH HHS; R01 DC04184/DC/NIDCD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzoates; 0/Bmp4 protein, mouse; 0/Bone Morphogenetic Protein 4; 0/Bone Morphogenetic Proteins; 0/Receptors, Retinoic Acid; 0/Retinoids; 0/retinoic acid receptor alpha; 0/retinoic acid receptor beta; 302-79-4/Tretinoin; 63231-63-0/RNA; 71441-28-6/4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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