Document Detail

Retinoic acid regulates IgG Fc receptor expression in human myelomonocytic leukemia cells and normal peripheral monocytes.
MedLine Citation:
PMID:  2972558     Owner:  NLM     Status:  MEDLINE    
The regulation of IgG Fc receptor (Fc gamma R) expression by retinoic acid (RA) in human myelomonocytic cells at different stages of maturation was studied. RA suppressed IgG-coated erythrocyte (EA) rosette formation of myelomonocytic cells blocked at relatively late stages of differentiation such as ML-1, U-937, THP-1-T, normal monocytes, and fresh cells of patients with acute myelomonocytic leukemia. However, RA increased the percentage of EA rosetting promyelocytes of HL-60 and of patients with acute promyelocytic leukemia and a part of myeloblasts isolated from acute myelogenous leukemia patients. Other myeloblasts including KG-1a, KG-1, and fresh cells from patients with acute myelogenous leukemia were not affected. A kinetic study using HL-60 and THP-1-T demonstrated that an increase required at least a 48-h exposure and that the maximum decrease required approximately 6 h. The RA effect on both cell lines was dose-dependent. The number of Fc gamma R of HL-60 and THP-1-T treated with RA became very close, although untreated THP-1 had almost 10 times as many as HL-60. Kd for IgG in both THP-1-T and HL-60, either untreated or treated with RA, remained unchanged. These observations indicate that one of the important roles of RA is regulation of Fc gamma R expression in myeloid cells.
T Nakamura; H Hemmi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of haematology     Volume:  41     ISSN:  0902-4441     ISO Abbreviation:  Eur. J. Haematol.     Publication Date:  1988 Sep 
Date Detail:
Created Date:  1988-11-29     Completed Date:  1988-11-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  258-66     Citation Subset:  IM    
Department of Bacteriology, Tohoku University, School of Medicine, Sendai, Japan.
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MeSH Terms
Antigens, Differentiation / metabolism*
Binding Sites / drug effects
Cell Differentiation / drug effects
Cell Line
Immunoglobulin G / metabolism*
Leukemia, Myelomonocytic, Acute / immunology*,  pathology
Monocytes / cytology,  drug effects*,  metabolism
Receptors, Fc / metabolism*
Receptors, IgG
Rosette Formation
Tretinoin / pharmacology*
Reg. No./Substance:
0/Antigens, Differentiation; 0/Immunoglobulin G; 0/Receptors, Fc; 0/Receptors, IgG; 302-79-4/Tretinoin

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