Document Detail

Retinoic acid receptor beta2 and neurite outgrowth in the adult mouse spinal cord in vitro.
MedLine Citation:
PMID:  12235288     Owner:  NLM     Status:  MEDLINE    
Retinoic acid, acting through the nuclear retinoic acid receptor beta2 (RARbeta2), stimulates neurite outgrowth from peripheral nervous system tissue that has the capacity to regenerate neurites, namely, embryonic and adult dorsal root ganglia. Similarly, in central nervous system tissue that can regenerate, namely, embryonic mouse spinal cord, retinoic acid also stimulates neurite outgrowth and RARbeta2 is upregulated. By contrast, in the adult mouse spinal cord, which cannot regenerate, no such upregulation of RARbeta2 by retinoic acid is observed and no neurites are extended in vitro. To test our hypothesis that the upregulation of RARbeta2 is crucial to neurite regeneration, we have transduced adult mouse or rat spinal cord in vitro with a minimal equine infectious anaemia virus vector expressing RARbeta2. After transduction, prolific neurite outgrowth occurs. Outgrowth does not occur when the cord is transduced with a different isoform of RARbeta nor does it occur following treatment with nerve growth factor. These data demonstrate that RARbeta2 is involved in neurite outgrowth, at least in vitro, and that this gene may in the future be of some therapeutic use.
Jonathan Corcoran; Po-Lin So; Robert D Barber; Karen J Vincent; Nicholas D Mazarakis; Kyriacos A Mitrophanous; Susan M Kingsman; Malcolm Maden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cell science     Volume:  115     ISSN:  0021-9533     ISO Abbreviation:  J. Cell. Sci.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-17     Completed Date:  2003-03-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0052457     Medline TA:  J Cell Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  3779-86     Citation Subset:  IM    
MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, Guy's Campus, London SE1 1UL, UK.
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MeSH Terms
Aging / genetics,  metabolism
Cell Differentiation / drug effects,  genetics*
Cells, Cultured
Gene Expression Regulation, Developmental / genetics
Genetic Vectors / genetics,  therapeutic use
Lentivirus / genetics
Nerve Growth Factors / metabolism*,  pharmacology
Nerve Regeneration / genetics*
Neurites / drug effects,  metabolism*,  ultrastructure
Neurofilament Proteins / metabolism
Receptors, Retinoic Acid / drug effects,  genetics,  metabolism*
Spinal Cord / cytology,  growth & development*,  metabolism
Transduction, Genetic
Tretinoin / metabolism*,  pharmacology
Reg. No./Substance:
0/Nerve Growth Factors; 0/Neurofilament Proteins; 0/Receptors, Retinoic Acid; 0/retinoic acid receptor beta; 302-79-4/Tretinoin

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