Document Detail

Retinoic acid receptor-beta: an endogenous inhibitor of the perinatal formation of pulmonary alveoli.
MedLine Citation:
PMID:  11074013     Owner:  NLM     Status:  MEDLINE    
Pulmonary alveoli are formed, in part, by subdivision (septation) of the gas-exchange saccules of the immature lung. Septation is developmentally regulated, and failure to septate at the appropriate time is not followed by delayed spontaneous septation. We report retinoic acid receptor (RAR) beta knockout mice exhibit premature septation; in addition, they form alveoli twice as fast as wild-type mice during the period of septation but at the same rate as wild-type mice thereafter. Consistent with the perinatal effect of RARbeta knockout, RARbeta agonist treatment of newborn rats impairs septation. These results 1) identify RARbeta as the first recognized endogenous signaling that inhibits septation, 2) demonstrate premature onset of septation may be induced, and 3) show the molecular signaling regulating alveolus formation differs during and after the period of septation. Suppressing perinatal RARbeta signaling by RARbeta antagonists may offer a novel, nonsurgical, means of preventing, or remediating, failed septation in prematurely born children.
G D Massaro; D Massaro; W Y Chan; L B Clerch; N Ghyselinck; P Chambon; R A Chandraratna
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2000-11-09
Journal Detail:
Title:  Physiological genomics     Volume:  4     ISSN:  1531-2267     ISO Abbreviation:  Physiol. Genomics     Publication Date:  2000 Nov 
Date Detail:
Created Date:  2000-11-21     Completed Date:  2001-02-15     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9815683     Medline TA:  Physiol Genomics     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  51-7     Citation Subset:  IM    
Lung Biology Laboratory, Department of Pediatrics, Georgetown University School of Medicine, Washington District of Columbia 20007-2197, USA.
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MeSH Terms
Animals, Newborn / growth & development*
Growth Inhibitors / physiology*
Mice, Inbred C57BL
Mice, Inbred Strains
Mice, Knockout
Pulmonary Alveoli / growth & development*,  pathology
Rats, Sprague-Dawley
Receptors, Retinoic Acid / agonists,  metabolism,  physiology*
Signal Transduction / physiology
Grant Support
Reg. No./Substance:
0/Growth Inhibitors; 0/Receptors, Retinoic Acid; 0/retinoic acid receptor beta

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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