Document Detail

Retinoic acid protects Langerhans' cells from the effects of the tumour promotor 12-O-tetradecanoylphorbol 13-acetate.
MedLine Citation:
PMID:  2759656     Owner:  NLM     Status:  MEDLINE    
Retinoic acid prevents the decrease in epidermal Langerhans' cell (LC) density which occurs upon application of the tumour promotor 12-O-tetradecanoylphorbol 13-acetate (TPA) to murine skin. This occurred very rapidly, after only 1 week, and was still observed after 4 weeks of treatment. Retinoic acid alone increased the LC density, indicating that it could affect LC density independently of TPA. The induction of a contact sensitivity response which was inhibited by prior treatment with TPA due to the low LC density was also protected by retinoic acid. The anti-carcinogenic activity of retinoic acid is partially the result of its ability to inhibit tumour promotion. The loss of LC may be one of the important steps in tumour promotion as this would allow developing tumours to escape immune destruction. Our studies suggest that the ability of retinoic acid to suppress tumour promotion may be in part by protecting local antigen-presenting cells, thus allowing an immune response to be generated against tumours.
G M Halliday; J L Dickinson; H K Muller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Immunology     Volume:  67     ISSN:  0019-2805     ISO Abbreviation:  Immunology     Publication Date:  1989 Jul 
Date Detail:
Created Date:  1989-09-08     Completed Date:  1989-09-08     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  298-302     Citation Subset:  IM    
Department of Pathology, University of Tasmania, Hobart, Australia.
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MeSH Terms
Cell Count
Dermatitis, Contact / immunology
Langerhans Cells / drug effects*
Mice, Inbred BALB C
Tetradecanoylphorbol Acetate*
Tretinoin / pharmacology*
Reg. No./Substance:
16561-29-8/Tetradecanoylphorbol Acetate; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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