Document Detail

Retinoic acid, meiosis and germ cell fate in mammals.
MedLine Citation:
PMID:  17715177     Owner:  NLM     Status:  MEDLINE    
Although mammalian sex is determined genetically, the sex-specific development of germ cells as sperm or oocytes is initiated by cues provided by the gonadal environment. During embryogenesis, germ cells in an ovary enter meiosis, thereby committing to oogenesis. By contrast, germ cells in a testicular environment do not enter meiosis until puberty. Recent findings indicate that the key to this sex-specific timing of meiosis entry is the presence or absence of the signaling molecule retinoic acid. Although this knowledge clarifies a long-standing mystery in reproductive biology, it also poses many new questions, which we discuss in this review.
Josephine Bowles; Peter Koopman
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2007-08-22
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  134     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-10     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  England    
Other Details:
Languages:  eng     Pagination:  3401-11     Citation Subset:  IM    
Division of Molecular Genetics and Development, and ARC Centre of Excellence in Biotechnology and Development, Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
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MeSH Terms
Cell Differentiation
Cell Movement
Cell Proliferation
Germ Cells / drug effects,  physiology*
Meiosis / drug effects,  genetics,  physiology*
Models, Biological
Sex Differentiation
Sexual Maturation
Testis / cytology,  drug effects
Tretinoin / pharmacology,  physiology*
Urogenital System / embryology
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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