| Retinoic acid: a key player in immunity. | |
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MedLine Citation:
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PMID: 20803520 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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For the past 100 years, vitamin A has been implicated as an essential dietary component in host resistance to infectious disease. However, only recently have studies begun to elucidate the cellular and molecular mechanisms of how vitamin A regulates cell-mediated and humoral-mediated immunity. In this review, we present an overview of the recent discoveries of the role that vitamin A and its metabolite, retinoic acid (RA), play in the regulation of immune cells. How RA impacts on leukocyte growth, differentiation, and homing is discussed with special attention to inflammatory responses and solid tumor microenvironment. |
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Authors:
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Karina Pino-Lagos; Yanxia Guo; Randolph J Noelle |
Publication Detail:
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Type: Journal Article Date: 2010-08-27 |
Journal Detail:
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Title: BioFactors (Oxford, England) Volume: 36 ISSN: 1872-8081 ISO Abbreviation: Biofactors Publication Date: 2010 Nov-Dec |
Date Detail:
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Created Date: 2010-12-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8807441 Medline TA: Biofactors Country: Netherlands |
Other Details:
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Languages: eng Pagination: 430-6 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 International Union of Biochemistry and Molecular Biology, Inc. |
Affiliation:
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Department of Microbiology and Immunology, Dartmouth Medical School, Lebanon, NH, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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