Document Detail

Retinoic acid inhibits the production of collagenase by human epidermal keratinocytes.
MedLine Citation:
PMID:  2153179     Owner:  NLM     Status:  MEDLINE    
Lattices made of collagen and fibroblasts can be used as dermal equivalents to grow human keratinocytes in vitro. When these cultures are performed in a medium containing delipidized serum, the lattice is eventually degraded by the growing epithelium. The digestion of the dermal equivalent is due to the secretion of a collagenase by the keratinocytes. This degradation does not occur in cultures containing total serum or supplemented with retinoic acid. We show in this paper that retinoic acid inhibits the secretion of this keratinocyte collagenase in a dose-dependent manner. In the light of this result, the possible involvement of collagenase inhibition in the therapeutic effect of retinoic acid in skin disorders and skin aging must be considered.
C Bailly; S Drèze; D Asselineau; B Nusgens; C M Lapière; M Darmon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of investigative dermatology     Volume:  94     ISSN:  0022-202X     ISO Abbreviation:  J. Invest. Dermatol.     Publication Date:  1990 Jan 
Date Detail:
Created Date:  1990-02-09     Completed Date:  1990-02-09     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0426720     Medline TA:  J Invest Dermatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  47-51     Citation Subset:  IM    
Cell Biology Department, Centre International de Recherches Dermatologiques (CIRD), Sophia Antipolis, France.
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MeSH Terms
Blood Physiological Phenomena
Collagen / metabolism
Culture Techniques
Dose-Response Relationship, Drug
Epidermis / cytology*
Keratinocytes / enzymology*,  metabolism
Microbial Collagenase / biosynthesis*,  secretion
Tretinoin / pharmacology*
Reg. No./Substance:
302-79-4/Tretinoin; 9007-34-5/Collagen; EC Collagenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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