| Retinoic acid inhibits the myristoylation of a membrane protein in HL-60 cells. | |
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MedLine Citation:
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PMID: 2241975 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Incubation of nondifferentiated HL-60 cells with high specific activity myristic acid results in myristoylation of a 25 KD membrane protein. Myristoylation was inhibited by retinoic acid but not by DMSO, thus indicating that the nonmyristoylated state induced by retinoic acid is causal to rather than the result of the overall differentiation sequel induced. Similarly, incubation of HL-60 cells with high specific activity retinoic acid results in specific retinoylation of a membrane protein of similar molecular mass. The two acylated proteins could however be separated by 2-D gel electrophoresis, thus indicating that inhibition of myristoylation by retinoic acid could not be accounted for by competition between retinoic and myristic acids for the same acylated site. |
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Authors:
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M Almagor; J Bar-Tana |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 172 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1990 Oct |
Date Detail:
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Created Date: 1990-12-05 Completed Date: 1990-12-05 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 877-82 Citation Subset: IM |
Affiliation:
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Department of Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation
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drug effects Cell Line Dimethyl Sulfoxide / pharmacology Electrophoresis, Polyacrylamide Gel Humans Leukemia, Promyelocytic, Acute Membrane Proteins / isolation & purification, metabolism* Molecular Weight Myristic Acid Myristic Acids / metabolism* Tretinoin / metabolism, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Membrane Proteins; 0/Myristic Acids; 302-79-4/Tretinoin; 544-63-8/Myristic Acid; 67-68-5/Dimethyl Sulfoxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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