Document Detail


Retinoic acid induces alveolar regeneration in the adult mouse lung.
MedLine Citation:
PMID:  14738226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent data suggests that exogenous retinoic acid (RA) can induce alveolar regeneration in a mouse and a rat model of experimental emphysema and disrupted alveolar development. This may be because RA is required during normal alveolar development and the subsequent provision of RA reawakens the gene cascades used during development. Here, additional evidence that RA is required during alveologenesis in the mouse is provided by showing that disulphiram disrupts this process. A further model of disrupted alveolar development using dexamethasone administered postnatally is then described, and it is further shown that RA administered to these adult mice restores the lung architecture to normal. Alveolar regeneration with retinoic acid may therefore be an important novel therapeutic approach to the treatment of respiratory diseases characterised by a reduced gas-exchanging surface area, such as bronchopulmonary dysplasia and emphysema.
Authors:
M Hind; M Maden
Related Documents :
22087786 - Scope and mechanistic studies of electrophilic alkoxyetherification.
10645966 - Retinoic acid inhibition of cardiac mesenchyme formation in vitro correlates with chang...
7349886 - Cell fusion, haemolysis and mitochondrial swelling induced by retinol and derivatives.
19700416 - Acidic retinoids synergize with vitamin a to enhance retinol uptake and stra6, lrat, an...
2847946 - Synthesis of acylated sod derivatives which bind to the biomembrane lipid surface and d...
9915266 - Abnormal renal vasodilation to an amino acid infusion in congestive heart failure: norm...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The European respiratory journal     Volume:  23     ISSN:  0903-1936     ISO Abbreviation:  Eur. Respir. J.     Publication Date:  2004 Jan 
Date Detail:
Created Date:  2004-01-23     Completed Date:  2004-04-27     Revised Date:  2013-05-23    
Medline Journal Info:
Nlm Unique ID:  8803460     Medline TA:  Eur Respir J     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  20-7     Citation Subset:  IM    
Affiliation:
Medical Research Council Centre for Developmental Neurobiology, King's College London, London, UK.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aldehyde Oxidoreductases / antagonists & inhibitors
Animals
Dexamethasone / pharmacology
Female
Male
Mice
Pulmonary Alveoli / physiology*
Regeneration / physiology
Retinal Dehydrogenase
Tretinoin / pharmacology*
Chemical
Reg. No./Substance:
302-79-4/Tretinoin; 50-02-2/Dexamethasone; EC 1.2.-/Aldehyde Oxidoreductases; EC 1.2.1.36/Retinal Dehydrogenase
Comments/Corrections
Comment In:
Eur Respir J. 2004 Jan;23(1):3-4   [PMID:  14738221 ]
Eur Respir J. 2004 Aug;24(2):331-2; author reply 332   [PMID:  15332408 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Nuclear YB-1 expression as a negative prognostic marker in nonsmall cell lung cancer.
Next Document:  The 6-min walk distance: change over time and value as a predictor of survival in severe COPD.