Document Detail

Retinoic acid enhances nephron endowment in rats exposed to maternal protein restriction.
MedLine Citation:
PMID:  17849154     Owner:  NLM     Status:  MEDLINE    
A reduced nephron complement at birth renders the kidney susceptible to renal disease in adulthood. Retinoic acid (RA; the active metabolite of vitamin A) is linked to nephrogenesis in vitro and in vivo. The aim of this study was to determine the effect of administration of retinoic acid in midgestation in rats on nephron endowment in offspring exposed to maternal protein restriction. Rats were fed either a normal-protein diet (NPD) or a low-protein diet (LPD) during pregnancy and lactation. Half of the dams in the LPD group were injected intraperitoneally with retinoic acid (20 mg/kg) during gestation at embryonic day 11.5. At 4 weeks of age, the offspring were anesthetized and perfusion-fixed, and nephron number estimated using unbiased stereological techniques. Body weight and kidney volume was significantly reduced in all LPD offspring. There was a significant 29% reduction in nephron number in the LPD group compared with the NPD offspring, whereas the number of nephrons in kidneys from the LPD + RA offspring was not significantly different compared with controls. In conclusion, administration of a single bolus dose of retinoic acid during midgestation restored nephron endowment to normal in offspring exposed to maternal protein restriction.
John Makrakis; Monika A Zimanyi; M Jane Black
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Publication Detail:
Type:  Journal Article     Date:  2007-09-12
Journal Detail:
Title:  Pediatric nephrology (Berlin, Germany)     Volume:  22     ISSN:  0931-041X     ISO Abbreviation:  Pediatr. Nephrol.     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-01     Completed Date:  2007-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8708728     Medline TA:  Pediatr Nephrol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1861-7     Citation Subset:  IM    
Department of Anatomy & Cell Biology, Monash University, Post Office Box 13C, Melbourne, VIC 3800, Australia.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Body Weight / drug effects
Diet, Protein-Restricted
Dietary Proteins / pharmacology*
Fetal Nutrition Disorders / drug therapy*,  pathology
Gestational Age
Injections, Intraperitoneal
Kidney Glomerulus / abnormalities,  drug effects,  pathology
Nephrons / abnormalities*,  drug effects,  pathology
Organ Size / drug effects
Prenatal Exposure Delayed Effects / drug therapy*
Rats, Inbred WKY
Tretinoin / pharmacology*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Dietary Proteins; 302-79-4/Tretinoin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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