| Retinoic acid can block differentiation of the myocardium after heart specification. | |
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MedLine Citation:
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PMID: 9268569 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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While a number of transcription factors that are likely to play a role in cardiac differentiation have recently been described, the signals that lead to the expression of these factors remains poorly understood. Here we report that exposure of Xenopus embryos to continuous low levels of all-trans retinoic acid (RA), starting at the time of neural fold closure, blocks expression of myocardial differentiation markers. The development of the remainder of the embryo is relatively normal, suggesting that retinoic acid can act rather specifically on myocardial precursors. Indeed, the pattern of endocardial gene expression appears to remain unaffected by RA treatment. Although RA blocks myocardial gene expression, a superficially normal heart tube forms. The heart tube, however, fails to loop during subsequent development and never forms beating tissue. The effect of RA treatment on expression of myocardial genes is developmental stage dependent, since no influence is observed after myocardial differentiation has commenced. These data indicate that a vital component of the myocardial determination pathway is sensitive to retinoid signaling. |
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Authors:
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T A Drysdale; K D Patterson; M Saha; P A Krieg |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Developmental biology Volume: 188 ISSN: 0012-1606 ISO Abbreviation: Dev. Biol. Publication Date: 1997 Aug |
Date Detail:
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Created Date: 1997-10-01 Completed Date: 1997-10-01 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372762 Medline TA: Dev Biol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 205-15 Citation Subset: IM |
Affiliation:
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Institute for Cellular and Molecular Biology and Department of Zoology, University of Texas at Austin, Austin, Texas, 78712, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation / drug effects* Embryo, Nonmammalian / cytology, physiology* Gene Expression Regulation, Developmental / drug effects Heart / drug effects, embryology* Morphogenesis Organ Culture Techniques Stem Cells / cytology, drug effects, physiology Tretinoin / pharmacology* Xenopus laevis / embryology |
| Grant Support | |
ID/Acronym/Agency:
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HL52746/HL/NHLBI NIH HHS; IBN9553176//PHS HHS; IR15HD32080-01A1/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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302-79-4/Tretinoin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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