| Retinoic acid from the meninges regulates cortical neuron generation. | |
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MedLine Citation:
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PMID: 19879845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Extrinsic signals controlling generation of neocortical neurons during embryonic life have been difficult to identify. In this study we demonstrate that the dorsal forebrain meninges communicate with the adjacent radial glial endfeet and influence cortical development. We took advantage of Foxc1 mutant mice with defects in forebrain meningeal formation. Foxc1 dosage and loss of meninges correlated with a dramatic reduction in both neuron and intermediate progenitor production and elongation of the neuroepithelium. Several types of experiments demonstrate that retinoic acid (RA) is the key component of this secreted activity. In addition, Rdh10- and Raldh2-expressing cells in the dorsal meninges were either reduced or absent in the Foxc1 mutants, and Rdh10 mutants had a cortical phenotype similar to the Foxc1 null mutants. Lastly, in utero RA treatment rescued the cortical phenotype in Foxc1 mutants. These results establish RA as a potent, meningeal-derived cue required for successful corticogenesis. |
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Authors:
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Julie A Siegenthaler; Amir M Ashique; Konstantinos Zarbalis; Katelin P Patterson; Jonathan H Hecht; Maureen A Kane; Alexandra E Folias; Youngshik Choe; Scott R May; Tsutomu Kume; Joseph L Napoli; Andrew S Peterson; Samuel J Pleasure |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell Volume: 139 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2009 Oct |
Date Detail:
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Created Date: 2009-11-02 Completed Date: 2009-12-03 Revised Date: 2013-02-27 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 597-609 Citation Subset: IM |
Affiliation:
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Department of Neurology, Institute for Regenerative Medicine, University of California San Francisco, San Francisco, CA 94158, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Forkhead Transcription Factors / genetics, metabolism Meninges / metabolism* Mice Neurogenesis* Neurons / cytology* Prosencephalon / cytology, metabolism Tretinoin / metabolism* |
| Grant Support | |
ID/Acronym/Agency:
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AS1625//Autism Speaks; K02 MH074958-05/MH/NIMH NIH HHS; R01 DA017627-11A1/DA/NIDA NIH HHS; R01DA017627/DA/NIDA NIH HHS; R56 DA017627-11/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Forkhead Transcription Factors; 0/Foxc1 protein, mouse; 302-79-4/Tretinoin |
| Comments/Corrections | |
Erratum In:
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Cell. 2011 Aug 5;146(3):486 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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