Document Detail


Retinoblastoma in Nepal: a clinical profile of 30 cases.
MedLine Citation:
PMID:  17203823     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To determine the clinical profile of retinoblastoma and to provide baseline data for further studies on this subject. Prospective evaluation of 30 consecutive patients with retinoblastoma admitted at the B. P. Koirala Lions Center for Ophthalmic Studies, Kathmandu, Nepal, between October 1998 and July 2000 was carried out. Age, sex, laterality and time from onset of symptoms to diagnosis (lag time) were noted. Ancillary tests were undertaken to rule out metastasis. Male to female ratio was 1.1:1 and the median age of presentation was 3.1 years. Of 30 cases, 23 (76.6%) had unilateral involvement. Leukocoria was the presenting sign in 13 cases (43.3%) and fungating mass in 10 cases (33.3%). In 11 (36.7%), the latency period from onset of symptoms to diagnosis was 6-12 months. In bilateral cases, advanced disease was treated surgically and the fellow eye was treated with cryotherapy, photocoagulation and chemotherapy. Histopathological examination of 21 (70.0%) enucleated/exenterated cases revealed a poorly differentiated type of retinoblastoma. This is the first study of retinoblastoma from Nepal. Early diagnosis of this disease when it is localized to the eye is important to salvage the life of the child. An informational program directed toward the public in general, as well as careful screening of any white pupillary reflex by the pediatrician and/or primary health worker will encourage and support early diagnosis.
Authors:
Rohit Saiju; Jaya Thakur; Purna Chandra Karmacharya; Dev Narayan Shah
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nepal Medical College journal : NMCJ     Volume:  8     ISSN:  -     ISO Abbreviation:  Nepal Med Coll J     Publication Date:  2006 Sep 
Date Detail:
Created Date:  2007-01-05     Completed Date:  2007-03-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129937     Medline TA:  Nepal Med Coll J     Country:  Nepal    
Other Details:
Languages:  eng     Pagination:  171-5     Citation Subset:  IM    
Affiliation:
Tilganga Eye Center, Kathmandu, Nepal. rohitsaiju@hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Disease Progression
Female
Humans
Infant
Infant, Newborn
Male
Nepal / epidemiology
Prospective Studies
Retinal Neoplasms / epidemiology*,  pathology,  therapy
Retinoblastoma / epidemiology*,  pathology,  therapy
Risk Assessment
Risk Factors
Time Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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