| RETINAS OF THE DIURNAL RODENT ARVICANTHIS ANSORGEI ARE HIGHLY RESISTANT TO EXPERIMENTALLY-INDUCED STRESS AND DEGENERATION. | |
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MedLine Citation:
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PMID: 21960552 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Purpose.Environmentally-induced stress plays a significant role in retinal degeneration and blindness, both in animals and humans. Among such sources of stress, phototoxicity is well studied and has been shown to lead to photoreceptor-specific loss in a number of species. However, the vast majority of studies has been conducted in nocturnal, albino rod-dominant rat and mouse strains, and the pertinence of such findings to human pathology and cone loss is debatable. We thus examined the retinal vulnerability to damage in the diurnal murid rodent Arvicanthis ansorgei, a pigmented species possessing a large number of cones.Methods.We used established protocols for either: 1) exposing animals to a wide range of lighting conditions (variable intensity, duration, spectrum, previous light history and time of exposure); and 2) injection of N-methyl-nitrosourea (MNU), both reported to produce rapid and complete photoreceptor-specific damage. Animals then underwent electroretinography to record rod and cone function, and were subsequently euthanized and used for immunohistochemical analysis of retinal structure and quantification of free fatty acids.Results.Using these standard regimes, there were no detectable detrimental effects on Arvicanthis retinal phenotype, function or structure. Partial retinal damage in Arvicanthis was induced by very intense blue light or elevated doses of MNU. This resistance was not due to differences in lipid composition (specifically docosahexaenoic acid) between Arvicanthis and susceptible strains of mice and rats.Conclusion.The retina of this species exhibits exceptionally high resistance to damage from light and toxins such as MNU. |
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Authors:
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Domitille L Boudard; Niyazi Acar; Lionel Bretillon; David Hicks |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-9-29 |
Journal Detail:
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Title: Investigative ophthalmology & visual science Volume: - ISSN: 1552-5783 ISO Abbreviation: - Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-9-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7703701 Medline TA: Invest Ophthalmol Vis Sci Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Département de Neurobiologie des Rythmes, CNRS UPR 3212 Université de Strasbourg, Institut des Neurosciences Cellulaires et Intégratives, 5 rue Blaise Pascal, 67084 Strasbourg Cedex, France. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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