Document Detail


Retinal waves coordinate patterned activity throughout the developing visual system.
MedLine Citation:
PMID:  23060192     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The morphological and functional development of the vertebrate nervous system is initially governed by genetic factors and subsequently refined by neuronal activity. However, fundamental features of the nervous system emerge before sensory experience is possible. Thus, activity-dependent development occurring before the onset of experience must be driven by spontaneous activity, but the origin and nature of activity in vivo remains largely untested. Here we use optical methods to show in live neonatal mice that waves of spontaneous retinal activity are present and propagate throughout the entire visual system before eye opening. This patterned activity encompassed the visual field, relied on cholinergic neurotransmission, preferentially initiated in the binocular retina and exhibited spatiotemporal correlations between the two hemispheres. Retinal waves were the primary source of activity in the midbrain and primary visual cortex, but only modulated ongoing activity in secondary visual areas. Thus, spontaneous retinal activity is transmitted through the entire visual system and carries patterned information capable of guiding the activity-dependent development of complex intra- and inter-hemispheric circuits before the onset of vision.
Authors:
James B Ackman; Timothy J Burbridge; Michael C Crair
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nature     Volume:  490     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2012 Oct 
Date Detail:
Created Date:  2012-10-12     Completed Date:  2012-11-06     Revised Date:  2014-10-22    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  219-25     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Bicyclo Compounds, Heterocyclic / pharmacology
Calcium / metabolism
Gene Expression Regulation, Developmental / drug effects
Mice
Mice, Inbred C57BL
Nicotinic Agonists / pharmacology
Pyridines / pharmacology
Retina / drug effects,  growth & development
Retinal Neurons / cytology,  drug effects
Visual Cortex / cytology,  drug effects,  growth & development*
Grant Support
ID/Acronym/Agency:
P30 EY000785/EY/NEI NIH HHS; P30 EY000785/EY/NEI NIH HHS; R01 EY015788/EY/NEI NIH HHS; R01 EY015788/EY/NEI NIH HHS; R01 EY023105/EY/NEI NIH HHS; T15LM070506/LM/NLM NIH HHS; T32 EY017353/EY/NEI NIH HHS; T32 EY022312/EY/NEI NIH HHS; T32 NS007224/NS/NINDS NIH HHS; T32NS007224/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Bicyclo Compounds, Heterocyclic; 0/Nicotinic Agonists; 0/Pyridines; 140111-52-0/epibatidine; SY7Q814VUP/Calcium
Comments/Corrections

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