| Retinal vessel diameters and risk of hypertension: the Multiethnic Study of Atherosclerosis. | |
| | |
MedLine Citation:
|
PMID: 19680136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To describe the prospective relationship of retinal vessel diameters with risk of hypertension in a multiethnic population-based cohort. METHODS: The Multi-Ethnic Study of Atherosclerosis is a population-based study of subclinical cardiovascular disease among white, African-American, Hispanic, and Chinese American adults aged 45-84 years. Retinal vessel diameters were measured using a standardized imaging software at the second examination (considered baseline in this analysis) and summarized as the central retinal artery/vein equivalent. Presence of retinopathy and retinal focal arteriolar narrowing and arteriovenous nicking was assessed by trained graders. Incidence of hypertension was defined among participants at risk as systolic blood pressure at least 140 mmHg, diastolic blood pressure at least 90 mmHg, or use of an antihypertensive medication. RESULTS: Of the initial 6237 participants at baseline, 2583 were at risk of hypertension. After 3.2 +/- 0.5 years of follow-up, 448 (17.3%) participants developed hypertension. After adjusting for age, sex, race/ethnicity, the average of mean arterial blood pressure in the first and second examination, and other vascular risk factors, persons with narrower retinal arteriolar diameter and wider venular diameter at baseline were more likely to develop hypertension [odds ratio per SD decrease in central retinal artery equivalent 1.20, 95% confidence intervals 1.02, 1.42; and odds ratio per SD increase in central retinal vein equivalent 1.18, 95% confidence interval 1.02, 1.37]. Persons with focal arteriolar narrowing were also more likely to develop hypertension (odds ratio 1.80, 95% confidence interval 1.09, 2.97). CONCLUSION: Findings from this multiethnic population confirm that narrower retinal arteriolar diameter and wider venular diameter are associated with the development of hypertension independent of traditional risk factors. |
| | |
Authors:
|
Ryo Kawasaki; Ning Cheung; Jie Jin Wang; Ronald Klein; Barbara Ek Klein; Mary Frances Cotch; A Richey Sharrett; Steven Shea; Fm Amirul Islam; Tien Y Wong |
Related Documents
:
|
22183616 - High pressure transport properties of the topological insulator bi(2)se(3). 1858026 - Effects of distention and short-term grafting on vasoreactivity in rabbit external jugu... 10502206 - Comparison of vessel dilator and long-acting natriuretic peptide in the treatment of co... 18698936 - Pressure vessel for tensile testing in high-pressure gases at elevated temperatures. 10322936 - Stimulation of locus coeruleus increases arterial pressure in rabbits. 11776136 - Clinical significance of changes in beta-adrenoreceptors in peripheral lymphocytes in p... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural |
Journal Detail:
|
Title: Journal of hypertension Volume: 27 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2009 Dec |
Date Detail:
|
Created Date: 2009-11-20 Completed Date: 2010-01-19 Revised Date: 2013-06-02 |
Medline Journal Info:
|
Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
|
Languages: eng Pagination: 2386-93 Citation Subset: IM |
Affiliation:
|
Department of Ophthalmology, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Melbourne, Australia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aged, 80 and over Atherosclerosis / ethnology, etiology, pathology* Capillaries / pathology Disease Progression Female Humans Hypertension / diagnosis*, ethnology, physiopathology Male Microcirculation / physiology Middle Aged Predictive Value of Tests Retinal Diseases / diagnosis*, ethnology, physiopathology Retinal Vessels / pathology* Risk Assessment United States / ethnology Vasoconstriction / physiology |
| Grant Support | |
ID/Acronym/Agency:
|
N01-HC-95159/HC/NHLBI NIH HHS; N01-HC-95160/HC/NHLBI NIH HHS; N01-HC-95161/HC/NHLBI NIH HHS; N01-HC-95162/HC/NHLBI NIH HHS; N01-HC-95163/HC/NHLBI NIH HHS; N01-HC-95164/HC/NHLBI NIH HHS; N01-HC-95165/HC/NHLBI NIH HHS; N01-HC-95169/HC/NHLBI NIH HHS; R01HL69979/HL/NHLBI NIH HHS; Z01 EY000403-06/EY/NEI NIH HHS; Z01 EY000403-07/EY/NEI NIH HHS; Z01EY00403/EY/NEI NIH HHS; Z99 EY999999/EY/NEI NIH HHS; ZIA EY000403-08/EY/NEI NIH HHS; ZIA EY000403-09/EY/NEI NIH HHS; ZIA EY000403-10/EY/NEI NIH HHS |
| Comments/Corrections | |
Comment In:
|
J Hypertens. 2009 Dec;27(12):2346-8
[PMID:
19920733
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Stimulation of AT2 receptor exerts beneficial effects in stroke-prone rats: focus on renal damage.
Next Document: Adenine/cytosine(1166) polymorphism of the angiotensin II type 1 receptor gene and the antihypertens...