Document Detail


Retinal vein pulsation is in phase with intracranial pressure and not intraocular pressure.
MedLine Citation:
PMID:  22700710     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: As efforts to noninvasively measure intracranial pressure (ICP) increase, we thought it important to investigate the timing of retinal venous pulsation in relation to the intraocular and intracranial pressure pulses.
METHODS: Neurosurgical patients undergoing continuous direct ICP monitoring had video recordings of ICP, IOP, and retinal venous pulsation waveforms taken with constant timing relative to the cardiac cycle using pulse oximetry. Video frames of the maxima and minima of these parameters, including retinal vein diameter, were identified. The times from pulse oximetry "beep" to these parameters were measured and converted into a percentage of the respective cardiac cycle.
RESULTS: A total of 338 measurements from nine subjects with a mean age of 39 years, mean ICP of 4.4 mm Hg and IOP 15.1 mm Hg were taken. Vein diameter minima occurred an insignificant 0.6% of cardiac cycle before ICP minima (P = 0.6620) and a significant 3.2% after IOP minima (P = 0.0097) and significantly later than IOP (51%) and ICP maxima (74%, all P < 0.0001). Maximum vein diameter occurred an insignificant 2.0% before IOP maxima (P = 0.2267) and was significantly different from IOP and ICP minima (P < 0.00001). Mean venous pulsation pressure between the two eyes was significantly associated with ICP (r = 0.89, P = 0.0075).
CONCLUSIONS: During pulsation, central retinal vein collapse occurs in time with IOP and ICP diastole. Venous collapse is not induced by intraocular systole. These results suggest that ICP pulse pressure dominates the timing of venous pulsation.
Authors:
William H Morgan; Christopher R P Lind; Samuel Kain; Naeem Fatehee; Arul Bala; Dao-Yi Yu
Publication Detail:
Type:  Journal Article     Date:  2012-07-10
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  53     ISSN:  1552-5783     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-12     Completed Date:  2012-09-24     Revised Date:  2013-01-09    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4676-81     Citation Subset:  IM    
Affiliation:
Lions Eye Institute, Centre for Ophthalmology and Visual Science, Nedlands, WA, Australia. whmorgan@cyllene.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Intracranial Hypertension / physiopathology*
Intracranial Pressure / physiology*
Intraocular Pressure / physiology*
Male
Middle Aged
Oximetry
Pulse
Regression Analysis
Retinal Vein / physiopathology*
Tonometry, Ocular
Young Adult
Comments/Corrections
Comment In:
Invest Ophthalmol Vis Sci. 2012 Sep;53(10):6045   [PMID:  22962442 ]

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