Document Detail


Retinal vein occlusion: evaluation of "classic" and "emerging" risk factors and treatment.
MedLine Citation:
PMID:  19669864     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retinal vein occlusion (RVO) is the second most common retinal vein disease and an important cause of blindness and visual morbidity. Systemic risk factors are commonly associated with RVO, while unclear it is the role of the thrombophilic and coagulation disorders. To evaluate "classic" and "emerging" risk factors, and to establish a good treatment for RVO. Fifty patients, 31 males and 19 females, with RVO were selected for our study. RVO patients were divided into two groups: those with central retinal vein occlusion (CRVO) and those with branch retinal vein occlusion (BRVO). All patients were subjected to an anamnestic investigation and were tested for thrombophilia, coagulation disorders and hyperlipidemia. Treatment and prophylaxis were evaluated. We have named "classic" the systemic risk factors associated with RVO and "emerging" those risk factors, haemostasis related, not clearly associated with RVO. RVO occurs more commonly in patients aged over 50. "Emerging" risk factors were more frequent in CRVO, "classic" in BRVO. Hyperhomocysteinemia is the most common "emerging" risk factor related to RVO. 71.4% of tested patients had hypercholesterolemia. Treatment with LMWH would appear to be safe and effective, but the small number of patients considered not allow us a definitive evaluation of its efficacy. Although our study has shown the correlation between RVO and the "emerging" risk factors, more studies are necessary to better know the real role of thrombophilic and coagulation disorders in this disease and to determine a specific protocol for the treatment and prophylaxis of RVO.
Authors:
Marina Turello; Samantha Pasca; Roberto Daminato; Patrizia Dello Russo; Roberta Giacomello; Ugo Venturelli; Giovanni Barillari
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of thrombosis and thrombolysis     Volume:  29     ISSN:  1573-742X     ISO Abbreviation:  J. Thromb. Thrombolysis     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-05-10     Completed Date:  2010-08-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9502018     Medline TA:  J Thromb Thrombolysis     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  459-64     Citation Subset:  IM    
Affiliation:
Center for Hemorrhagic and Thrombotic Diseases, General University Hospital of Udine, Udine, Italy.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Blindness / etiology,  mortality
Blood Coagulation Disorders / complications,  mortality*
Female
Humans
Hypercholesterolemia / complications,  mortality*
Hyperhomocysteinemia / complications,  mortality*
Male
Middle Aged
Retinal Vein Occlusion / etiology,  mortality*,  prevention & control
Risk Factors
Thrombophilia / complications,  mortality*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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