Document Detail

Retinal vasoreactivity as a marker for chronic ischemic white matter disease?
MedLine Citation:
PMID:  22687956     Owner:  NLM     Status:  MEDLINE    
STUDY GOALS: To examine (1) the association between cerebral ischemic white matter disease (WMD) and retinal microvessel behavior and (2) the relationship between retinal blood vessel reactivity and measures of cerebrovascular function.
METHODS: Cohort study of 12 patients with ischemic WMD and 14 healthy controls. Retinal vasoreactivity was measured following high frequency flicker light stimulation. Middle cerebral artery (MCA) vasoreactivity was measured using transcranial Doppler ultrasound (TCD). Magnetic resonance imaging scans (MRIs) were reviewed for evidence of ischemic WMD.
RESULTS: Patients with ischemic WMD had attenuated retinal venous (2.2% ± 0.27 SD, vs. controls 6% ± 0.7 SD, p=0.002, CI 95%) and arterial (1.9% ± 0.8 SD, vs. controls 4.9% ± 0.8 SD, p=0.004, CI 95%) vasoreactivity compared to controls. An attenuated retinal venous light flicker response was associated with a significant decrease of MCA vasoreactivity (r=0.45, p=0.05, CI 95%). Decreased AVRs, an indicator for altered retinal vessel architecture in patients with cerebral chronic ischemic WMD, were also significantly correlated with dysfunction of cerebral vasoreactivity (r=0.69, p=0.001, CI 95%).
CONCLUSION: In this study functional and structural impairment of the retinal microvasculature were associated with ischemic WMD and measures of cerebral vascular function. Microvascular dysfunction in the eye may predict cerebral small vessel disease, but validation by larger studies is needed.
Kerstin Bettermann; Julia E Slocomb; Vikram Shivkumar; Mary E J Lott
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-06-10
Journal Detail:
Title:  Journal of the neurological sciences     Volume:  322     ISSN:  1878-5883     ISO Abbreviation:  J. Neurol. Sci.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-22     Completed Date:  2013-04-11     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  0375403     Medline TA:  J Neurol Sci     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  206-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Department of Neurology, Penn State College of Medicine, Hershey, PA, USA.
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MeSH Terms
Aged, 80 and over
Brain / pathology*
Chronic Disease
Leukoencephalopathies / complications,  pathology*
Linear Models
Magnetic Resonance Imaging
Middle Aged
Reproducibility of Results
Retinal Vessels / pathology,  physiopathology*
Stroke / complications,  pathology*
Ultrasonography, Doppler, Transcranial

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