Document Detail

Retinal vascular changes following supplementation with alpha-tocopherol or beta-carotene.
MedLine Citation:
PMID:  9541437     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To examine if long-term supplementation with alpha-tocopherol (AT) or beta-carotene (BC) was associated with the prevalence of vascular changes in retinal arterioles. METHODS: An end-of-trial subsample from a double-blind, placebo-controlled clinical trial designed to study the effects of alpha-tocopherol and beta-carotene on lung cancer incidence (ATBC Study). SETTING: Source population of Helsinki and the surrounding province. PARTICIPANTS: 1072 men 50-69 years old and smoking at least 5 cigarettes per day at study entry. INTERVENTIONS: Random allocation to one of four supplementation regimens: 50 mg per day alpha-tocopherol, 20 mg per day beta-carotene, both alpha-tocopherol and beta-carotene, or placebo. Median follow-up time was 6.6 years (range 5.2-8.0 years). MAIN OUTCOME MEASURE: Presence of vascular changes in retinal arterioles as determined from end-of-trial retinal color photographs. RESULTS: Retinal vascular changes were most prevalent in the AT (161 men, 62%), and in the BC (163 men, 62%) groups. The prevalence rate was lowest in the AT plus BC group (161 men, 55%), and slightly higher in the placebo group (145 men, 57%). There was no statistically significant association of either AT (OR 0.9, 95% CI 0.7-1.2) or BC (OR 1.0, 95% CI 0.8-1.3) supplementation with the prevalence of retinal vascular changes after adjusting for major risk factors. CONCLUSIONS: Supplementation with alpha-tocopherol or beta-carotene for a median of 6.6 years does not protect against retinal vascular changes among smoking males.
J M Teikari; L Laatikainen; J M Rapola; J Virtamo; J Haukka; K Liesto; P Taylor; O P Heinonen
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Acta ophthalmologica Scandinavica     Volume:  76     ISSN:  1395-3907     ISO Abbreviation:  Acta Ophthalmol Scand     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-05-05     Completed Date:  1998-05-05     Revised Date:  2008-03-17    
Medline Journal Info:
Nlm Unique ID:  9507578     Medline TA:  Acta Ophthalmol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  68-73     Citation Subset:  IM    
University of Helsinki, Department of Public Health, Finland.
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MeSH Terms
Aged, 80 and over
Antioxidants / administration & dosage*
Arterioles / pathology
Arteriosclerosis / epidemiology,  etiology,  pathology
Double-Blind Method
Finland / epidemiology
Follow-Up Studies
Hypertension / epidemiology,  etiology,  pathology
Middle Aged
Retinal Artery / pathology*
Retinal Diseases / epidemiology,  etiology,  pathology
Smoking / adverse effects
Vitamin E / administration & dosage*
beta Carotene / administration & dosage*
Grant Support
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 7235-40-7/beta Carotene

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