Document Detail

Retinal vascular calibre is altered in patients with rheumatoid arthritis: a biomarker of disease activity and cardiovascular risk?
MedLine Citation:
PMID:  21172929     Owner:  NLM     Status:  Publisher    
Objectives. Alterations in retinal vascular calibre, particularly wider venular calibre, have been independently associated with elevated markers of inflammation and cardiovascular risk in the general population. We hypothesized that retinal vascular calibre would be altered in patients with RA, who are known to have both elevated cardiovascular risk and chronic, systemic inflammation. Methods. Retinal vascular calibre was measured from digital retinal photographs using computerized methods in 51 RA patients and 51 age- and gender-matched controls. Retinal vascular calibre was compared between RA and control patients with adjustment for relevant variables including cardiovascular risk factors and companion vessel calibre. The relationship between retinal venular calibre and inflammation was assessed by comparing controls and RA patients with high and lower disease activity. Results. Retinal venular calibre [mean (s.d.)] was significantly wider in RA patients than in controls [235.9 (24.6) vs 211.6 (21.0) µm, P < 0.001]. After adjustment for all relevant variables, mean venular calibre remained 20.3 µm (95% CI 10.4, 30.3) wider in RA patients compared with controls. Retinal venular calibre [mean (s.d.)] also increased with increasing levels of systemic inflammation: 211.6 (21.0) µm in controls, 232.3 (22.4) µm in RA patients with moderate or lower disease activity and 255.5 (28.3) µm in RA patients with high disease activity (P for trend <0.0001). Conclusions. This study demonstrates that RA patients have dilated retinal venular calibre, reflecting systemic inflammation and possibly increased cardiovascular risk. Longitudinal studies correlating retinal vascular calibre with subsequent cardiovascular events will clarify the clinical utility of this test in patients with RA.
Sharon Van Doornum; Gemma Strickland; Ryo Kawasaki; Jing Xie; Ian P Wicks; Lauren A B Hodgson; Tien Y Wong
Related Documents :
7482439 - Decreased fibrinolytic stimulation by a short-term venous occlusion test in patients wi...
12199669 - Efficacy and safety of a factor viii-von willebrand factor concentrate 8y: stability, b...
11167789 - Treatment of coagulation inhibitors with extracorporeal immunoadsorption (ig-therasorb).
3704999 - Rabbit polyclonal antibodies against the calcium-dependent conformation of factor ix an...
12406009 - Acquired hemophilia: a single-center survey with emphasis on immunotherapy and treatmen...
6194079 - Report of the fifth homozygous patient with factor vii padua defect.
11150629 - Troglitazone, an antidiabetic drug, improves left ventricular mass and diastolic functi...
8161729 - Lean body mass estimation by creatinine kinetics.
21832819 - Oxytocin immunoreactivity in the corpus cavernosum of patients with erectile dysfunction.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-12-20
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  -     ISSN:  1462-0332     ISO Abbreviation:  -     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Medicine (RMH/WH), University of Melbourne, Department of Rheumatology, Royal Melbourne Hospital, Melbourne Health, Melbourne, Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, University of Melbourne, Victoria, Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia and Singapore Eye Research Institute, National University of Singapore, Singapore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor...
Next Document:  A novel regulatory circuit in base excision repair involving AP endonuclease 1, Creb1 and DNA polyme...