Document Detail

Retinal toxicity of indocyanine green.
MedLine Citation:
PMID:  17581700     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To describe a case of scattered toxicity of indocyanine green on the outer retina and retinal pigment epithelium (RPE) after indocyanine green (ICG) assisted membrane peeling for macular pucker. METHODS: A 61-year-old woman was examined by slit-lamp biomicroscopy, fluorescein angiography (FA), indocyanine green angiography (ICGA) and optical coherence tomography (OCT), 1 month and 1 year after ICG assisted membrane peeling for macular pucker. RESULTS: In the absence of significant fundoscopic changes, we have noted on FA and ICGA an occurrence of scattered unusual outer retinal and pigment epithelial changes at the 1- and the 12-month follow-up, probably due to the enhanced phototoxicity associated with the use of ICG at a high concentration (0.5%). CONCLUSIONS: Retinal toxicity of ICG in macular surgery depends on many factors. In our patient, the retinal changes seem to have been caused by a combination of all the toxic factors. This is the first reported case describing both the angiographic and OCT patterns of diffuse scattered toxicity of ICG on outer retinal layers and pigment epithelium after ICG assisted membrane peeling for macular pucker.
Giuseppe Querques; Francesco Prascina; Cristiana Iaculli; Nicola Delle Noci
Publication Detail:
Type:  Case Reports; Journal Article     Date:  2007-06-21
Journal Detail:
Title:  International ophthalmology     Volume:  28     ISSN:  0165-5701     ISO Abbreviation:  Int Ophthalmol     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-09     Completed Date:  2008-07-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7904294     Medline TA:  Int Ophthalmol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  115-8     Citation Subset:  IM    
Department of Ophthalmology, Policlinico Riuniti di Foggia, University of Foggia, Viale Pinto, 1, Foggia 71100, Italy.
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MeSH Terms
Coloring Agents / adverse effects*,  diagnostic use
Epiretinal Membrane / surgery*
Fluorescein Angiography
Indocyanine Green / adverse effects*,  diagnostic use
Middle Aged
Pigment Epithelium of Eye / drug effects
Retina / drug effects*,  pathology
Tomography, Optical Coherence
Reg. No./Substance:
0/Coloring Agents; 3599-32-4/Indocyanine Green

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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